{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao D"],"funding":["American Cancer Society","NIAID NIH HHS","NHLBI NIH HHS","NCI NIH HHS","NIH"],"pagination":["4970-4979"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6205404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["128(11)"],"pubmed_abstract":["Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract remains the major cause of morbidity and nonrelapse mortality after BM transplantation (BMT). The Paneth cell protein regenerating islet-derived 3α (REG3α) is a biomarker specific for GI GVHD. REG3α serum levels rose in the systematic circulation as GVHD progressively destroyed Paneth cells and reduced GI epithelial barrier function. Paradoxically, GVHD suppressed intestinal REG3γ (the mouse homolog of human REG3α), and the absence of REG3γ in BMT recipients intensified GVHD but did not change the composition of the microbiome. IL-22 administration restored REG3γ production and prevented apoptosis of both intestinal stem cells (ISCs) and Paneth cells, but this protection was completely abrogated in Reg3g-/- mice. In vitro,"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease."],"pmcid":["PMC6205404"],"funding_grant_id":["CRP-13-306-06-COUN","T32 HL007622","P30 CA008748","T32 AI078892","5T32AI078892","R01 CA228308","R01 CA228358","P01 CA039542"],"pubmed_authors":["Ozbek U","Hooper LV","Greenson JK","Harris AC","Stappenbeck TS","Slingerland AE","Levine JE","Peled JU","Ferrara JL","Donovan MJ","Ver Heul A","Chaudhry MS","Gomes AL","Kim YH","Jeong S","van den Brink MR","Liu TC","Zhao D","Anderson ER","Hoepting M","Reddy P"],"additional_accession":[]},"is_claimable":false,"name":"Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease.","description":"Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract remains the major cause of morbidity and nonrelapse mortality after BM transplantation (BMT). The Paneth cell protein regenerating islet-derived 3α (REG3α) is a biomarker specific for GI GVHD. REG3α serum levels rose in the systematic circulation as GVHD progressively destroyed Paneth cells and reduced GI epithelial barrier function. Paradoxically, GVHD suppressed intestinal REG3γ (the mouse homolog of human REG3α), and the absence of REG3γ in BMT recipients intensified GVHD but did not change the composition of the microbiome. IL-22 administration restored REG3γ production and prevented apoptosis of both intestinal stem cells (ISCs) and Paneth cells, but this protection was completely abrogated in Reg3g-/- mice. In vitro,","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-07-16T16:27:13.057Z","creation":"2019-03-26T22:47:30Z"},"accession":"S-EPMC6205404","cross_references":{"pubmed":["30106382"],"doi":["10.1172/JCI99261","10.1172/jci99261"]}}