{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Gao YJ"],"pubmed_abstract":["<h4>Background</h4>The poor prognosis of colorectal cancer (CRC) largely results from local invasion and tumor metastases. Epithelial-mesenchymal transition (EMT) is a key step in the progression of solid tumors and plays a vital role in tumor metastasis. Recent studies demonstrate that C-X-C motif chemokine 11 (CXCL11) is involved in various cancers' progression. However, its biological activity in CRC needs deeper exploration.<h4>Methods</h4>The level of CXCL11 in CRC tissues and cell lines was determined using the quantitative real-time PCR (qRT-PCR) assay. The MTT, colony formation, wound healing and Transwell invasion assays were applied to assess the role of CXCL11 in CRC cell growth, migration and invasion, in vitro, respectively. A xenograft model was constructed to analyze the fun"],"journal":["OncoTargets and therapy"],"pagination":["7333-7343"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6205823"],"repository":["biostudies-literature"],"pubmed_title":["Down-regulation of CXCL11 inhibits colorectal cancer cell growth and epithelial-mesenchymal transition."],"pmcid":["PMC6205823"],"pubmed_authors":["Liu L","Li S","Zhu HY","Gao YJ","Yuan GF","Li L","Cao GY"],"additional_accession":[]},"is_claimable":false,"name":"Down-regulation of CXCL11 inhibits colorectal cancer cell growth and epithelial-mesenchymal transition.","description":"<h4>Background</h4>The poor prognosis of colorectal cancer (CRC) largely results from local invasion and tumor metastases. Epithelial-mesenchymal transition (EMT) is a key step in the progression of solid tumors and plays a vital role in tumor metastasis. Recent studies demonstrate that C-X-C motif chemokine 11 (CXCL11) is involved in various cancers' progression. However, its biological activity in CRC needs deeper exploration.<h4>Methods</h4>The level of CXCL11 in CRC tissues and cell lines was determined using the quantitative real-time PCR (qRT-PCR) assay. The MTT, colony formation, wound healing and Transwell invasion assays were applied to assess the role of CXCL11 in CRC cell growth, migration and invasion, in vitro, respectively. A xenograft model was constructed to analyze the fun","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-25T18:00:38.034Z","creation":"2019-03-27T00:07:36Z"},"accession":"S-EPMC6205823","cross_references":{"pubmed":["30425523"],"doi":["10.2147/OTT.S167872"]}}