biostudies-literatureUnknown11Gao YJ<h4>Background</h4>The poor prognosis of colorectal cancer (CRC) largely results from local invasion and tumor metastases. Epithelial-mesenchymal transition (EMT) is a key step in the progression of solid tumors and plays a vital role in tumor metastasis. Recent studies demonstrate that C-X-C motif chemokine 11 (CXCL11) is involved in various cancers' progression. However, its biological activity in CRC needs deeper exploration.<h4>Methods</h4>The level of CXCL11 in CRC tissues and cell lines was determined using the quantitative real-time PCR (qRT-PCR) assay. The MTT, colony formation, wound healing and Transwell invasion assays were applied to assess the role of CXCL11 in CRC cell growth, migration and invasion, in vitro, respectively. A xenograft model was constructed to analyze the funOncoTargets and therapy7333-7343https://www.ebi.ac.uk/biostudies/studies/S-EPMC6205823biostudies-literatureDown-regulation of CXCL11 inhibits colorectal cancer cell growth and epithelial-mesenchymal transition.PMC6205823Liu LLi SZhu HYGao YJYuan GFLi LCao GYfalseDown-regulation of CXCL11 inhibits colorectal cancer cell growth and epithelial-mesenchymal transition.<h4>Background</h4>The poor prognosis of colorectal cancer (CRC) largely results from local invasion and tumor metastases. Epithelial-mesenchymal transition (EMT) is a key step in the progression of solid tumors and plays a vital role in tumor metastasis. Recent studies demonstrate that C-X-C motif chemokine 11 (CXCL11) is involved in various cancers' progression. However, its biological activity in CRC needs deeper exploration.<h4>Methods</h4>The level of CXCL11 in CRC tissues and cell lines was determined using the quantitative real-time PCR (qRT-PCR) assay. The MTT, colony formation, wound healing and Transwell invasion assays were applied to assess the role of CXCL11 in CRC cell growth, migration and invasion, in vitro, respectively. A xenograft model was constructed to analyze the fun2018-01-01T00:00:00Z20182025-04-25T18:00:38.034Z2019-03-27T00:07:36ZS-EPMC62058233042552310.2147/OTT.S167872