biostudies-literatureUnknown19(10)Yasuma TCrizotinib is highly effective against anaplastic lymphoma kinase-positive and c-ros oncogen1-positive non-small cell lung cancer. Renal dysfunction is associated with crizotinib therapy but the mechanism is unknown. Here, we report a case of anaplastic lymphoma kinase positive non-small cell lung cancer showing multiple cysts and dysfunction of the kidneys during crizotinib administration. We also present results demonstrating that long-term crizotinib treatment induces fibrosis and dysfunction of the kidneys by activating the tumor necrosis factor-α/nuclear factor-κB signaling pathway. In conclusion, this study shows the renal detrimental effects of crizotinib, suggesting the need of careful monitoring of renal function during crizotinib therapy.International journal of molecular sciencesE2902https://www.ebi.ac.uk/biostudies/studies/S-EPMC6213486biostudies-literatureRenal Injury during Long-Term Crizotinib Therapy.PMC6213486Baffour Tonto PYonemura SKobayashi TNishihama KToda MTakeshita AFujimoto HTaguchi OYasuma TIto KD'Alessandro-Gabazza CNGabazza ECNishii YHataji OfalseRenal Injury during Long-Term Crizotinib Therapy.Crizotinib is highly effective against anaplastic lymphoma kinase-positive and c-ros oncogen1-positive non-small cell lung cancer. Renal dysfunction is associated with crizotinib therapy but the mechanism is unknown. Here, we report a case of anaplastic lymphoma kinase positive non-small cell lung cancer showing multiple cysts and dysfunction of the kidneys during crizotinib administration. We also present results demonstrating that long-term crizotinib treatment induces fibrosis and dysfunction of the kidneys by activating the tumor necrosis factor-α/nuclear factor-κB signaling pathway. In conclusion, this study shows the renal detrimental effects of crizotinib, suggesting the need of careful monitoring of renal function during crizotinib therapy.2018-01-01T00:00:00Z2018 Sep2026-07-15T18:15:59.503Z2025-05-31T22:24:59.698ZS-EPMC62134863025743710.3390/ijms19102902