biostudies-literatureMilagres LFIC NIH HHS2500https://www.ebi.ac.uk/biostudies/studies/S-EPMC6215828biostudies-literatureUnknown9Since 2006, meningococcal serogroup C (MenC) conjugate (MCC) vaccines have been supplied by the Brazilian government for HIV-infected children under 13 years old. For measuring protection against MenC, the serum bactericidal antibody (SBA) assay is the method of choice. The characterization of T follicular helper cells (TFH) cells has been an area of intensive study because of their significance in multiple human diseases and in vaccinology. The objective of this study was to characterize the phenotype of peripheral TFH cells and B cells and how they associated with each other and with SBA levels induced by vaccination as well as with serum cytokine levels of HIV-infected and non-infected children and adolescents. We found that CD27^-IgD^-CD21^-CD38<sup>+</supFrontiers in immunologyBaseline Circulating Activated TFH and Tissue-Like Exhausted B Cells Negatively Correlate With Meningococcal C Conjugate Vaccine Induced Antibodies in HIV-Infected Individuals.PMC6215828R01 TW008397Coelho BSilva GFrota ACFerreira BVillela LPereira-Manfro WPetrovas CHofer CFigueredo MMilagres LBarreto DKoup RfalseBaseline Circulating Activated TFH and Tissue-Like Exhausted B Cells Negatively Correlate With Meningococcal C Conjugate Vaccine Induced Antibodies in HIV-Infected Individuals.Since 2006, meningococcal serogroup C (MenC) conjugate (MCC) vaccines have been supplied by the Brazilian government for HIV-infected children under 13 years old. For measuring protection against MenC, the serum bactericidal antibody (SBA) assay is the method of choice. The characterization of T follicular helper cells (TFH) cells has been an area of intensive study because of their significance in multiple human diseases and in vaccinology. The objective of this study was to characterize the phenotype of peripheral TFH cells and B cells and how they associated with each other and with SBA levels induced by vaccination as well as with serum cytokine levels of HIV-infected and non-infected children and adolescents. We found that CD27^-IgD^-CD21^-CD38<sup>+</sup2018-01-01T00:00:00Z20182026-07-15T18:17:49.154Z2025-05-29T20:47:14.863ZS-EPMC62158283042085810.3389/fimmu.2018.02500