{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(20)"],"submitter":["Lu L"],"pubmed_abstract":["The nucleolus is a dynamic structure that has roles in various physiological and pathophysiological processes. Perturbations on many aspects of the nucleolar functions are thought to cause \"nucleolar stress\", which occurs in response to a variety of chemotherapeutic drugs. The main characteristic changes of nucleolar stress include: 1) reduction of the size and volume of the nucleolus; 2) inhibition of RNA Pol I-mediated rRNA synthesis; and 3) nucleoplasmic translocation of nucleolar stress-related proteins. In studying the apoptosis-inducing effect of the natural compound lovastatin (LV) on breast cancer stem cells, we unexpectedly uncovered a novel form of nucleolar stress, which we call \"reverse nucleolar stress\". In our system, the canonical nucleolus stress inducer doxorubicin caused "],"journal":["Journal of Cancer"],"pagination":["3723-3727"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6216007"],"repository":["biostudies-literature"],"pubmed_title":["Nucleolar stress: is there a reverse version?"],"pmcid":["PMC6216007"],"pubmed_authors":["Li G","Jiang Y","Lu L","Yi H","Deng T","He G","Yan S","Chen C","Yao H","Deng X"],"additional_accession":[]},"is_claimable":false,"name":"Nucleolar stress: is there a reverse version?","description":"The nucleolus is a dynamic structure that has roles in various physiological and pathophysiological processes. Perturbations on many aspects of the nucleolar functions are thought to cause \"nucleolar stress\", which occurs in response to a variety of chemotherapeutic drugs. The main characteristic changes of nucleolar stress include: 1) reduction of the size and volume of the nucleolus; 2) inhibition of RNA Pol I-mediated rRNA synthesis; and 3) nucleoplasmic translocation of nucleolar stress-related proteins. In studying the apoptosis-inducing effect of the natural compound lovastatin (LV) on breast cancer stem cells, we unexpectedly uncovered a novel form of nucleolar stress, which we call \"reverse nucleolar stress\". In our system, the canonical nucleolus stress inducer doxorubicin caused ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-05-29T20:47:26.399Z","creation":"2025-05-29T20:47:26.399Z"},"accession":"S-EPMC6216007","cross_references":{"pubmed":["30405843"],"doi":["10.7150/jca.27660"]}}