biostudies-literatureUnknown9(20)Lu LThe nucleolus is a dynamic structure that has roles in various physiological and pathophysiological processes. Perturbations on many aspects of the nucleolar functions are thought to cause "nucleolar stress", which occurs in response to a variety of chemotherapeutic drugs. The main characteristic changes of nucleolar stress include: 1) reduction of the size and volume of the nucleolus; 2) inhibition of RNA Pol I-mediated rRNA synthesis; and 3) nucleoplasmic translocation of nucleolar stress-related proteins. In studying the apoptosis-inducing effect of the natural compound lovastatin (LV) on breast cancer stem cells, we unexpectedly uncovered a novel form of nucleolar stress, which we call "reverse nucleolar stress". In our system, the canonical nucleolus stress inducer doxorubicin caused Journal of Cancer3723-3727https://www.ebi.ac.uk/biostudies/studies/S-EPMC6216007biostudies-literatureNucleolar stress: is there a reverse version?PMC6216007Li GJiang YLu LYi HDeng THe GYan SChen CYao HDeng XfalseNucleolar stress: is there a reverse version?The nucleolus is a dynamic structure that has roles in various physiological and pathophysiological processes. Perturbations on many aspects of the nucleolar functions are thought to cause "nucleolar stress", which occurs in response to a variety of chemotherapeutic drugs. The main characteristic changes of nucleolar stress include: 1) reduction of the size and volume of the nucleolus; 2) inhibition of RNA Pol I-mediated rRNA synthesis; and 3) nucleoplasmic translocation of nucleolar stress-related proteins. In studying the apoptosis-inducing effect of the natural compound lovastatin (LV) on breast cancer stem cells, we unexpectedly uncovered a novel form of nucleolar stress, which we call "reverse nucleolar stress". In our system, the canonical nucleolus stress inducer doxorubicin caused 2018-01-01T00:00:00Z20182025-05-29T20:47:26.399Z2025-05-29T20:47:26.399ZS-EPMC62160073040584310.7150/jca.27660