{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Orsini F"],"funding":["European Research Council"],"pagination":["2678-2690"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6221395"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(11)"],"pubmed_abstract":["Objective- Circulating complement factors are activated by tissue damage and contribute to acute brain injury. The deposition of MBL (mannose-binding lectin), one of the initiators of the lectin complement pathway, on the cerebral endothelium activated by ischemia is a major pathogenic event leading to brain injury. The molecular mechanisms through which MBL influences outcome after ischemia are not understood yet. Approach and Results- Here we show that MBL-deficient (MBL<sup>-/-</sup>) mice subjected to cerebral ischemia display better flow recovery and less plasma extravasation in the brain than wild-type mice, as assessed by in vivo 2-photon microscopy. This results in reduced vascular dysfunction as shown by the shift from a pro- to an anti-inflammatory vascular phenotype associated w"],"journal":["Arteriosclerosis, thrombosis, and vascular biology"],"pubmed_title":["Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α."],"pmcid":["PMC6221395"],"funding_grant_id":["724994"],"pubmed_authors":["Csaszar E","Orsini F","Denes A","Toth K","Fumagalli S","De Blasio D","Zangari R","De Simoni MG","Lenart N"],"additional_accession":[]},"is_claimable":false,"name":"Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α.","description":"Objective- Circulating complement factors are activated by tissue damage and contribute to acute brain injury. The deposition of MBL (mannose-binding lectin), one of the initiators of the lectin complement pathway, on the cerebral endothelium activated by ischemia is a major pathogenic event leading to brain injury. The molecular mechanisms through which MBL influences outcome after ischemia are not understood yet. Approach and Results- Here we show that MBL-deficient (MBL<sup>-/-</sup>) mice subjected to cerebral ischemia display better flow recovery and less plasma extravasation in the brain than wild-type mice, as assessed by in vivo 2-photon microscopy. This results in reduced vascular dysfunction as shown by the shift from a pro- to an anti-inflammatory vascular phenotype associated w","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-07-15T21:23:11.837Z","creation":"2026-07-09T10:13:41.91Z"},"accession":"S-EPMC6221395","cross_references":{"pubmed":["30354247"],"doi":["10.1161/ATVBAHA.118.311058"]}}