{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Torres-Mendoza D"],"funding":["Global Environmental Fund","Fogarty International Center’s International Cooperative Biodiversity Groups program","Fogarty International Center's International Cooperative Biodiversity Groups program","National System of Investigators (SNI)","Secretaría Nacional de Ciencia, Tecnología e Innovación"],"pagination":["E2179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6225264"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(9)"],"pubmed_abstract":["Chemical examination of the octocoral-associated <i>Bacillus</i> species (sp.) DT001 led to the isolation of pumilacidins A (<b>1</b>) and C (<b>2</b>). We investigated the effect of these compounds on the viability of <i>Plasmodium falciparum</i> and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca<sup>2+</sup>."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Pumilacidins from the Octocoral-Associated <i>Bacillus</i> sp. DT001 Display Anti-Proliferative Effects in <i>Plasmodium falciparum</i>."],"pmcid":["PMC6225264"],"funding_grant_id":["TW006634","81860","170-2016","COL09-047"],"pubmed_authors":["Guzman HM","Torres-Mendoza D","Gutierrez M","Pineda LM","Dorrestein PC","Spadafora C","Coronado LM"],"additional_accession":[]},"is_claimable":false,"name":"Pumilacidins from the Octocoral-Associated <i>Bacillus</i> sp. DT001 Display Anti-Proliferative Effects in <i>Plasmodium falciparum</i>.","description":"Chemical examination of the octocoral-associated <i>Bacillus</i> species (sp.) DT001 led to the isolation of pumilacidins A (<b>1</b>) and C (<b>2</b>). We investigated the effect of these compounds on the viability of <i>Plasmodium falciparum</i> and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca<sup>2+</sup>.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Aug","modification":"2026-04-30T09:19:28.085Z","creation":"2019-03-27T00:07:16Z"},"accession":"S-EPMC6225264","cross_references":{"pubmed":["30158478"],"doi":["10.3390/molecules23092179"]}}