biostudies-literatureTorres-Mendoza DGlobal Environmental FundFogarty International Center’s International Cooperative Biodiversity Groups programFogarty International Center's International Cooperative Biodiversity Groups programNational System of Investigators (SNI)Secretaría Nacional de Ciencia, Tecnología e InnovaciónE2179https://www.ebi.ac.uk/biostudies/studies/S-EPMC6225264biostudies-literatureUnknown23(9)Chemical examination of the octocoral-associated <i>Bacillus</i> species (sp.) DT001 led to the isolation of pumilacidins A (<b>1</b>) and C (<b>2</b>). We investigated the effect of these compounds on the viability of <i>Plasmodium falciparum</i> and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca²⁺.Molecules (Basel, Switzerland)Pumilacidins from the Octocoral-Associated <i>Bacillus</i> sp. DT001 Display Anti-Proliferative Effects in <i>Plasmodium falciparum</i>.PMC6225264TW00663481860170-2016COL09-047Guzman HMTorres-Mendoza DGutierrez MPineda LMDorrestein PCSpadafora CCoronado LMfalsePumilacidins from the Octocoral-Associated <i>Bacillus</i> sp. DT001 Display Anti-Proliferative Effects in <i>Plasmodium falciparum</i>.Chemical examination of the octocoral-associated <i>Bacillus</i> species (sp.) DT001 led to the isolation of pumilacidins A (<b>1</b>) and C (<b>2</b>). We investigated the effect of these compounds on the viability of <i>Plasmodium falciparum</i> and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca²⁺.2018-01-01T00:00:00Z2018 Aug2026-04-30T09:19:28.085Z2019-03-27T00:07:16ZS-EPMC62252643015847810.3390/molecules23092179