{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Salla RF"],"funding":["Brazilian Institute of Comparative Physiology","Foundation for support of research of São Paulo (FAPESP)","Coordination of Improvement of Higher Level Personnel CAPES (Master’s fellowship)","Research grant","National Council for Scientific and Technological Development - CNPq"],"pagination":["e5891"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6228586"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["<h4>Background</h4>Understanding of the physiological effects of chytridiomycosis is crucial to worldwide amphibian conservation. Therefore, we analyzed the cardiac function of two anuran species (<i>Xenopus laevis</i> and <i>Physalaemus albonotatus</i>) with different susceptibilities to infection by the causative agent of chytridiomycosis, <i>Batrachochytrium dendrobatidis</i> (hereafter <i>Bd</i>).<h4>Methods</h4>We analyzed the <i>in situ</i> heart rate (<i>f</i> <sub><i>H</i></sub> - bpm), relative ventricular mass (RVM -%), and Ca<sup>2+</sup> handling in heart of <i>Bd</i> infected animals compared to uninfected controls of both study species.<h4>Results</h4><i>Bd</i> infection resulted in a 78% decrease in contraction force values in <i>P. albonotatus</i> when compared to the less "],"journal":["PeerJ"],"pubmed_title":["Novel findings on the impact of chytridiomycosis on the cardiac function of anurans: sensitive vs. tolerant species."],"pmcid":["PMC6228586"],"funding_grant_id":["#2014/23388-7","08/57712-4","#405285/2013-2","573921/2008-3","#302589/2013-9"],"pubmed_authors":["Franco-Belussi L","Oliveira CR","Leite DS","Silva-Zacarin ECM","Salla RF","Jones-Costa M","Jenkinson TS","Lambertini C","Abdalla FC","Toledo LF","Rizzi-Possignolo GM"],"additional_accession":[]},"is_claimable":false,"name":"Novel findings on the impact of chytridiomycosis on the cardiac function of anurans: sensitive vs. tolerant species.","description":"<h4>Background</h4>Understanding of the physiological effects of chytridiomycosis is crucial to worldwide amphibian conservation. Therefore, we analyzed the cardiac function of two anuran species (<i>Xenopus laevis</i> and <i>Physalaemus albonotatus</i>) with different susceptibilities to infection by the causative agent of chytridiomycosis, <i>Batrachochytrium dendrobatidis</i> (hereafter <i>Bd</i>).<h4>Methods</h4>We analyzed the <i>in situ</i> heart rate (<i>f</i> <sub><i>H</i></sub> - bpm), relative ventricular mass (RVM -%), and Ca<sup>2+</sup> handling in heart of <i>Bd</i> infected animals compared to uninfected controls of both study species.<h4>Results</h4><i>Bd</i> infection resulted in a 78% decrease in contraction force values in <i>P. albonotatus</i> when compared to the less ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-07-07T03:10:09.96Z","creation":"2026-07-07T03:07:50.515Z"},"accession":"S-EPMC6228586","cross_references":{"pubmed":["30425891"],"doi":["10.7717/peerj.5891"]}}