{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pontremoli M"],"funding":["Ministry of Health, Italy | Agenzia Italiana del Farmaco, Ministero della Salute","Ministry of Health, Italy | Agenzia Italiana del Farmaco, Ministero della Salute (Italian Medicines Agency)"],"pagination":["16671"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6232108"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["This study shows that DKK-1, a member of the Dickkopf family and a regulator of the Wnt pathways, represents a novel target of statins which, through the inhibition of HMG-CoA reductase and of non-steroidal isoprenoid intermediates, exert extra-beneficial effect in preventing atherosclerosis beyond their effect on the lipid profile. We found that atorvastatin downregulates DKK-1 protein (-88.3 ± 4.1%) and mRNA expression (-90 ± 4.2%) through the inhibition of Cdc42, Rho and Rac geranylgeranylated proteins. Further, a combined approach based on the integration of label-free quantitative mass spectrometry based-proteomics and gene silencing allowed us to demonstrate that DKK-1 itself mediates, at least in part, statin effects on human endothelial cells. Indeed, DKK-1 is responsible for the r"],"journal":["Scientific reports"],"pubmed_title":["Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells."],"pmcid":["PMC6232108"],"funding_grant_id":["2101581"],"pubmed_authors":["Baetta R","Banfi C","Pontremoli M","Brioschi M","Ghilardi S"],"additional_accession":[]},"is_claimable":false,"name":"Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells.","description":"This study shows that DKK-1, a member of the Dickkopf family and a regulator of the Wnt pathways, represents a novel target of statins which, through the inhibition of HMG-CoA reductase and of non-steroidal isoprenoid intermediates, exert extra-beneficial effect in preventing atherosclerosis beyond their effect on the lipid profile. We found that atorvastatin downregulates DKK-1 protein (-88.3 ± 4.1%) and mRNA expression (-90 ± 4.2%) through the inhibition of Cdc42, Rho and Rac geranylgeranylated proteins. Further, a combined approach based on the integration of label-free quantitative mass spectrometry based-proteomics and gene silencing allowed us to demonstrate that DKK-1 itself mediates, at least in part, statin effects on human endothelial cells. Indeed, DKK-1 is responsible for the r","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-05-06T01:03:16.811Z","creation":"2019-03-27T00:10:15Z"},"accession":"S-EPMC6232108","cross_references":{"pubmed":["30420710"],"doi":["10.1038/s41598-018-35119-7"]}}