{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Thome AD"],"funding":["Ting Tsung and Wei Fong Chao Foundation in Houston, TX"],"pubmed_abstract":["<h4>Background</h4>Neuroinflammation is a hallmark of neurodegenerative disease and a significant component of the pathology of Alzheimer's disease (AD). Patients present with extensive microgliosis along with elevated pro-inflammatory signaling in the central nervous system and periphery. However, the role of peripheral myeloid cells in mediating and influencing AD pathogenesis remains unresolved.<h4>Methods</h4>Peripheral myeloid cells were isolated from peripheral blood of patients with prodromal AD (n = 44), mild AD dementia (n = 25), moderate/severe AD dementia (n = 28), and age-matched controls (n = 54). Patients were evaluated in the clinic for AD severity and categorized using Clinical Dementia Rating (CDR) scale resulting in separation of patients into prodromal AD (CDR0.5) and ad"],"journal":["Molecular neurodegeneration"],"pagination":["61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6233576"],"repository":["biostudies-literature"],"pubmed_title":["Functional alterations of myeloid cells during the course of Alzheimer's disease."],"pmcid":["PMC6233576"],"pubmed_authors":["Thonhoff JR","Thome AD","Zhao W","Appel SH","Masdeu JC","Wen S","Beers DR","Faridar A","Pascual B"],"additional_accession":[]},"is_claimable":false,"name":"Functional alterations of myeloid cells during the course of Alzheimer's disease.","description":"<h4>Background</h4>Neuroinflammation is a hallmark of neurodegenerative disease and a significant component of the pathology of Alzheimer's disease (AD). Patients present with extensive microgliosis along with elevated pro-inflammatory signaling in the central nervous system and periphery. However, the role of peripheral myeloid cells in mediating and influencing AD pathogenesis remains unresolved.<h4>Methods</h4>Peripheral myeloid cells were isolated from peripheral blood of patients with prodromal AD (n = 44), mild AD dementia (n = 25), moderate/severe AD dementia (n = 28), and age-matched controls (n = 54). Patients were evaluated in the clinic for AD severity and categorized using Clinical Dementia Rating (CDR) scale resulting in separation of patients into prodromal AD (CDR0.5) and ad","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-07-09T03:18:44.078Z","creation":"2019-03-27T00:08:25Z"},"accession":"S-EPMC6233576","cross_references":{"pubmed":["30424785"],"doi":["10.1186/s13024-018-0293-1"]}}