biostudies-literatureUnknown13(1)Thome ADTing Tsung and Wei Fong Chao Foundation in Houston, TX<h4>Background</h4>Neuroinflammation is a hallmark of neurodegenerative disease and a significant component of the pathology of Alzheimer's disease (AD). Patients present with extensive microgliosis along with elevated pro-inflammatory signaling in the central nervous system and periphery. However, the role of peripheral myeloid cells in mediating and influencing AD pathogenesis remains unresolved.<h4>Methods</h4>Peripheral myeloid cells were isolated from peripheral blood of patients with prodromal AD (n = 44), mild AD dementia (n = 25), moderate/severe AD dementia (n = 28), and age-matched controls (n = 54). Patients were evaluated in the clinic for AD severity and categorized using Clinical Dementia Rating (CDR) scale resulting in separation of patients into prodromal AD (CDR0.5) and adMolecular neurodegeneration61https://www.ebi.ac.uk/biostudies/studies/S-EPMC6233576biostudies-literatureFunctional alterations of myeloid cells during the course of Alzheimer's disease.PMC6233576Thonhoff JRThome ADZhao WAppel SHMasdeu JCWen SBeers DRFaridar APascual BfalseFunctional alterations of myeloid cells during the course of Alzheimer's disease.<h4>Background</h4>Neuroinflammation is a hallmark of neurodegenerative disease and a significant component of the pathology of Alzheimer's disease (AD). Patients present with extensive microgliosis along with elevated pro-inflammatory signaling in the central nervous system and periphery. However, the role of peripheral myeloid cells in mediating and influencing AD pathogenesis remains unresolved.<h4>Methods</h4>Peripheral myeloid cells were isolated from peripheral blood of patients with prodromal AD (n = 44), mild AD dementia (n = 25), moderate/severe AD dementia (n = 28), and age-matched controls (n = 54). Patients were evaluated in the clinic for AD severity and categorized using Clinical Dementia Rating (CDR) scale resulting in separation of patients into prodromal AD (CDR0.5) and ad2018-01-01T00:00:00Z2018 Nov2026-07-09T03:18:44.078Z2019-03-27T00:08:25ZS-EPMC62335763042478510.1186/s13024-018-0293-1