{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cox AG"],"funding":["American Liver Foundation","Stand Up To Cancer","National Institute of Diabetes and Digestive and Kidney Diseases","Pew Charitable Trusts","National Institutes of Health","National Institute of General Medical Sciences","NIDDK NIH HHS","NCI NIH HHS","National Health and Medical Research Council","Damon Runyon Cancer Research Foundation","NIGMS NIH HHS","NIH HHS","American-Italian Cancer Foundation"],"pagination":["e100294"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6236334"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(22)"],"pubmed_abstract":["The Hippo pathway and its nuclear effector Yap regulate organ size and cancer formation. While many modulators of Hippo activity have been identified, little is known about the Yap target genes that mediate these growth effects. Here, we show that <i>yap</i><sup>-/-</sup> mutant zebrafish exhibit defects in hepatic progenitor potential and liver growth due to impaired glucose transport and nucleotide biosynthesis. Transcriptomic and metabolomic analyses reveal that Yap regulates expression of glucose transporter glut1, causing decreased glucose uptake and use for nucleotide biosynthesis in <i>yap</i><sup>-/-</sup> mutants, and impaired glucose tolerance in adults. Nucleotide supplementation improves Yap deficiency phenotypes, indicating functional importance of glucose-fueled nucleotide bi"],"journal":["The EMBO journal"],"pubmed_title":["Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth."],"pmcid":["PMC6236334"],"funding_grant_id":["K08 DK105351","P30 CA006516","T32 GM007753","R01 DK090311","R01 DK105198","P01 CA120964","1146558","1R01DK090311","T32GM007753","T32 GM007287","R24 OD017870","P30 DK034854","P30DK034854","1R01DK105198","R24OD017870"],"pubmed_authors":["Steinhauser ML","Vander Heiden MG","Snay E","Hosios AM","Yimlamai D","Hwang KL","Yuan M","Galli GG","Sullivan MR","Lien EC","Ma KY","Fowl BH","Chhangawala S","Goessling W","Miesfeld J","Brown KK","Asara JM","Link B","Tsomides A","Fort M","Camargo FD","Cox AG","Houvras Y"],"additional_accession":[]},"is_claimable":false,"name":"Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.","description":"The Hippo pathway and its nuclear effector Yap regulate organ size and cancer formation. While many modulators of Hippo activity have been identified, little is known about the Yap target genes that mediate these growth effects. Here, we show that <i>yap</i><sup>-/-</sup> mutant zebrafish exhibit defects in hepatic progenitor potential and liver growth due to impaired glucose transport and nucleotide biosynthesis. Transcriptomic and metabolomic analyses reveal that Yap regulates expression of glucose transporter glut1, causing decreased glucose uptake and use for nucleotide biosynthesis in <i>yap</i><sup>-/-</sup> mutants, and impaired glucose tolerance in adults. Nucleotide supplementation improves Yap deficiency phenotypes, indicating functional importance of glucose-fueled nucleotide bi","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-04-16T11:32:22.296Z","creation":"2020-11-08T09:27:22Z"},"accession":"S-EPMC6236334","cross_references":{"pubmed":["30348863"],"doi":["10.15252/embj.2018100294"]}}