{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boublay N"],"funding":["National French Program of Hospital Clinical Research"],"pagination":["280"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6236893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<h4>Background</h4>One of the crucial challenges for the future of therapeutic approaches to Alzheimer's disease (AD) is to target the main pathological processes responsible for disability and dependency. However, a progressive cognitive impairment occurring after the age of 70, the main population affected by dementia, is often related to mixed lesions of neurodegenerative and vascular origins. Whereas young patients are mostly affected by pure lesions, ageing favours the occurrence of co-lesions of AD, cerebrovascular disease (CVD) and Lewy body dementia (LBD). Most of clinical studies report on functional and clinical disabilities in patients with presumed pure pathologies. But, the weight of co-morbid processes involved in the transition from an independent functional status to disabi"],"journal":["BMC geriatrics"],"pubmed_title":["Study protocol on Alzheimer's disease and related disorders: focus on clinical and imaging predictive markers in co-existing lesions."],"pmcid":["PMC6236893"],"funding_grant_id":["2012"],"pubmed_authors":["Boublay N","Grosmaitre P","Blanc F","Paccalin M","Bravant E","Bouet R","Pesce A","Relland S","Moreaud O","Verny M","Krolak-Salmon P","Desmidt T","Federico D"],"additional_accession":[]},"is_claimable":false,"name":"Study protocol on Alzheimer's disease and related disorders: focus on clinical and imaging predictive markers in co-existing lesions.","description":"<h4>Background</h4>One of the crucial challenges for the future of therapeutic approaches to Alzheimer's disease (AD) is to target the main pathological processes responsible for disability and dependency. However, a progressive cognitive impairment occurring after the age of 70, the main population affected by dementia, is often related to mixed lesions of neurodegenerative and vascular origins. Whereas young patients are mostly affected by pure lesions, ageing favours the occurrence of co-lesions of AD, cerebrovascular disease (CVD) and Lewy body dementia (LBD). Most of clinical studies report on functional and clinical disabilities in patients with presumed pure pathologies. But, the weight of co-morbid processes involved in the transition from an independent functional status to disabi","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2025-04-05T09:32:48.93Z","creation":"2019-03-27T00:08:42Z"},"accession":"S-EPMC6236893","cross_references":{"pubmed":["30428832"],"doi":["10.1186/s12877-018-0949-2"]}}