{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Narita Y"],"funding":["The INOUE ENRYO Memorial Grant"],"pubmed_abstract":["The neuroplastic mechanisms in the fish brain that underlie sex reversal remain unknown. Gonadotropin-releasing hormone 3 (GnRH3) neurons control male reproductive behaviours in Mozambique tilapia and show sexual dimorphism, with males having a greater number of GnRH3 neurons. Treatment with androgens such as 11-ketotestosterone (KT), but not 17β-estradiol, increases the number of GnRH3 neurons in mature females to a level similar to that observed in mature males. Compared with oestrogen, the effect of androgen on neurogenesis remains less clear. The present study examined the effects of 11-KT, a non-aromatizable androgen, on cellular proliferation, neurogenesis, generation of GnRH3 neurons and expression of cell cycle-related genes in mature females. The number of proliferating cell nucle"],"journal":["Scientific reports"],"pagination":["16855"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6237963"],"repository":["biostudies-literature"],"pubmed_title":["Androgen induced cellular proliferation, neurogenesis, and generation of GnRH3 neurons in the brain of mature female Mozambique tilapia."],"pmcid":["PMC6237963"],"pubmed_authors":["Lee JR","Tsutiya A","Hwang PP","Nakano Y","Ashitomi M","Hosono K","Ohtani-Kaneko R","Sato K","Tseng YC","Narita Y","Kaneko T","Chen RD"],"additional_accession":[]},"is_claimable":false,"name":"Androgen induced cellular proliferation, neurogenesis, and generation of GnRH3 neurons in the brain of mature female Mozambique tilapia.","description":"The neuroplastic mechanisms in the fish brain that underlie sex reversal remain unknown. Gonadotropin-releasing hormone 3 (GnRH3) neurons control male reproductive behaviours in Mozambique tilapia and show sexual dimorphism, with males having a greater number of GnRH3 neurons. Treatment with androgens such as 11-ketotestosterone (KT), but not 17β-estradiol, increases the number of GnRH3 neurons in mature females to a level similar to that observed in mature males. Compared with oestrogen, the effect of androgen on neurogenesis remains less clear. The present study examined the effects of 11-KT, a non-aromatizable androgen, on cellular proliferation, neurogenesis, generation of GnRH3 neurons and expression of cell cycle-related genes in mature females. The number of proliferating cell nucle","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-05-06T20:02:57.155Z","creation":"2019-03-27T00:08:49Z"},"accession":"S-EPMC6237963","cross_references":{"pubmed":["30442908"],"doi":["10.1038/s41598-018-35303-9"]}}