biostudies-literatureFoo SSNational Institute of Health124152https://www.ebi.ac.uk/biostudies/studies/S-EPMC6238739biostudies-literatureUnknown3(21)An intricate fetal-maternal immune crosstalk during pregnancy is essential for a healthy birth. Hence, the infection-induced alterations of maternal immunity often lead to adverse outcomes for mother and/or child. The emergence of Zika virus (ZIKV) infection in pregnant women has been associated with more than 3,000 cases of microcephaly and nervous system malformations. To explore the potential correlation of ZIKV-induced alteration of maternal immunity with fetal abnormalities, we performed extensive sera immunoprofiling of 74 pregnant women: 30 symptomatic ZIKV+ pregnant patients and 30 healthy pregnant controls in ZIKV-endemic Rio de Janeiro, along with 14 healthy pregnant controls in non-endemic Los Angeles. Extensive multiplexing analysis of 69 cytokines revealed that CXCL10, CCL2, aJCI insightBiomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies.PMC6238739CA200422,CA180779,DE023926,AI073099,AI116585,AI129496,AI140705,AI069120,AI056154,AI078389,AI28697,AI40718,AI129534-01Chan YNielsen-Saines KJung JUFoo SSChen WBrasil PLee SACheng GLee WSfalseBiomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies.An intricate fetal-maternal immune crosstalk during pregnancy is essential for a healthy birth. Hence, the infection-induced alterations of maternal immunity often lead to adverse outcomes for mother and/or child. The emergence of Zika virus (ZIKV) infection in pregnant women has been associated with more than 3,000 cases of microcephaly and nervous system malformations. To explore the potential correlation of ZIKV-induced alteration of maternal immunity with fetal abnormalities, we performed extensive sera immunoprofiling of 74 pregnant women: 30 symptomatic ZIKV+ pregnant patients and 30 healthy pregnant controls in ZIKV-endemic Rio de Janeiro, along with 14 healthy pregnant controls in non-endemic Los Angeles. Extensive multiplexing analysis of 69 cytokines revealed that CXCL10, CCL2, a2018-01-01T00:00:00Z2018 Nov2025-04-05T12:27:26.618Z2019-03-27T00:08:32ZS-EPMC62387393038572810.1172/jci.insight.124152