{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dai W"],"funding":["NEI NIH HHS","NCATS NIH HHS","American Diabetes Association","National Institutes of Health"],"pagination":["3568-3576"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6239931"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1864(12)"],"pubmed_abstract":["The incidence of type 2 diabetes, the most common cause of diabetic retinopathy (DR), is rapidly on the rise in developed countries due to overconsumption of calorie rich diets. Using an animal model of diet-induced obesity/pre-diabetes, we evaluated the impact of a diet high in saturated fat (HFD) on O-GlcNAcylation of retinal proteins, as dysregulated O-GlcNAcylation contributes to diabetic complications and evidence supports a role in DR. Protein O-GlcNAcylation was increased in the retina of mice fed a HFD as compared to littermates receiving control chow. Similarly, O-GlcNAcylation was elevated in retinal Müller cells in culture exposed to the saturated fatty acid palmitate or the ceramide analog Cer6. One potential mechanism responsible for elevated O-GlcNAcylation is increased flux "],"journal":["Biochimica et biophysica acta. Molecular basis of disease"],"pubmed_title":["Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression."],"pmcid":["PMC6239931"],"funding_grant_id":["R00 EY023612","K99 EY023612","UL1 TR002014","EY023612","1-14-INI-04","TL1 TR002016"],"pubmed_authors":["Dierschke SK","Dai W","Toro AL","Dennis MD"],"additional_accession":[]},"is_claimable":false,"name":"Consumption of a high fat diet promotes protein O-GlcNAcylation in mouse retina via NR4A1-dependent GFAT2 expression.","description":"The incidence of type 2 diabetes, the most common cause of diabetic retinopathy (DR), is rapidly on the rise in developed countries due to overconsumption of calorie rich diets. Using an animal model of diet-induced obesity/pre-diabetes, we evaluated the impact of a diet high in saturated fat (HFD) on O-GlcNAcylation of retinal proteins, as dysregulated O-GlcNAcylation contributes to diabetic complications and evidence supports a role in DR. Protein O-GlcNAcylation was increased in the retina of mice fed a HFD as compared to littermates receiving control chow. Similarly, O-GlcNAcylation was elevated in retinal Müller cells in culture exposed to the saturated fatty acid palmitate or the ceramide analog Cer6. One potential mechanism responsible for elevated O-GlcNAcylation is increased flux ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-05T09:52:54.258Z","creation":"2020-10-01T07:29:58Z"},"accession":"S-EPMC6239931","cross_references":{"pubmed":["30254013"],"doi":["10.1016/j.bbadis.2018.09.006"]}}