{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iwai M"],"funding":["Japan Society for the Promotion of Science"],"pagination":["e00944"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6240845"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(11)"],"pubmed_abstract":["Mitochondria are the powerhouses of eukaryotic cells and their positioning contributes to fertilization and early developmental processes. We report that sperm fusion triggers Ca<sup>2+</sup> oscillations and mitochondrial movement toward fused sperm (mitochondrial chemotaxis) in mouse eggs. Mitochondria functioned in Ca<sup>2+</sup> storage and were colocalized with endoplasmic reticulum (ER) during Ca<sup>2+</sup> oscillations. Mitochondria then moved toward the fused sperm. Sperm extracts lacking nuclei induced Ca<sup>2+</sup> oscillations, but did not promote mitochondrial chemotaxis. Our results suggest that sperm fusion motivates Ca<sup>2+</sup> oscillation-independent mitochondrial chemotaxis. This phenomenon indicates that egg mitochondria interact with sperm materials, presumably "],"journal":["Heliyon"],"pubmed_title":["Chemotactic behavior of egg mitochondria in response to sperm fusion in mice."],"pmcid":["PMC6240845"],"funding_grant_id":["26293363","16KK0192","26670733","18K16824","17K16850"],"pubmed_authors":["Kawano N","Harada Y","Kang W","Hamatani T","Yamada M","Yoshida K","Iwai M","Miyabayashi R","Nakamura A","Umezawa A","Miyado K","Miyado M","Saito H","Miyamoto Y","Tanaka M"],"additional_accession":[]},"is_claimable":false,"name":"Chemotactic behavior of egg mitochondria in response to sperm fusion in mice.","description":"Mitochondria are the powerhouses of eukaryotic cells and their positioning contributes to fertilization and early developmental processes. We report that sperm fusion triggers Ca<sup>2+</sup> oscillations and mitochondrial movement toward fused sperm (mitochondrial chemotaxis) in mouse eggs. Mitochondria functioned in Ca<sup>2+</sup> storage and were colocalized with endoplasmic reticulum (ER) during Ca<sup>2+</sup> oscillations. Mitochondria then moved toward the fused sperm. Sperm extracts lacking nuclei induced Ca<sup>2+</sup> oscillations, but did not promote mitochondrial chemotaxis. Our results suggest that sperm fusion motivates Ca<sup>2+</sup> oscillation-independent mitochondrial chemotaxis. This phenomenon indicates that egg mitochondria interact with sperm materials, presumably ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2025-04-04T08:41:44.837Z","creation":"2019-03-27T00:10:30Z"},"accession":"S-EPMC6240845","cross_references":{"pubmed":["30480160"],"doi":["10.1016/j.heliyon.2018.e00944"]}}