{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chiu H"],"funding":["NIGMS NIH HHS"],"pagination":["4842"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6242819"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Two important biological events happen coincidently soon after nerve injury in the peripheral nervous system in C. elegans: removal of axon debris and initiation of axon regeneration. But, it is not known how these two events are co-regulated. Mutants of ced-1, a homolog of Draper and MEGF10, display defects in both events. One model is that those events could be related. But our data suggest that they are actually separable. CED-1 functions in the muscle-type engulfing cells in both events and is enriched in muscle protrusions in close contact with axon debris and regenerating axons. Its two functions occur through distinct biochemical mechanisms; extracellular domain-mediated adhesion for regeneration and extracellular domain binding-induced intracellular domain signaling for debris remo"],"journal":["Nature communications"],"pubmed_title":["Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1."],"pmcid":["PMC6242819"],"funding_grant_id":["R01 GM098026","R01 GM111320"],"pubmed_authors":["Hsieh YW","Zou Y","Wu YC","Suzuki N","Chiu H","Chuang CF","Chang C"],"additional_accession":[]},"is_claimable":false,"name":"Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1.","description":"Two important biological events happen coincidently soon after nerve injury in the peripheral nervous system in C. elegans: removal of axon debris and initiation of axon regeneration. But, it is not known how these two events are co-regulated. Mutants of ced-1, a homolog of Draper and MEGF10, display defects in both events. One model is that those events could be related. But our data suggest that they are actually separable. CED-1 functions in the muscle-type engulfing cells in both events and is enriched in muscle protrusions in close contact with axon debris and regenerating axons. Its two functions occur through distinct biochemical mechanisms; extracellular domain-mediated adhesion for regeneration and extracellular domain binding-induced intracellular domain signaling for debris remo","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2025-04-04T08:41:18.228Z","creation":"2019-03-27T00:08:32Z"},"accession":"S-EPMC6242819","cross_references":{"pubmed":["30451835"],"doi":["10.1038/s41467-018-07291-x"]}}