biostudies-literatureChiu HNIGMS NIH HHS4842https://www.ebi.ac.uk/biostudies/studies/S-EPMC6242819biostudies-literatureUnknown9(1)Two important biological events happen coincidently soon after nerve injury in the peripheral nervous system in C. elegans: removal of axon debris and initiation of axon regeneration. But, it is not known how these two events are co-regulated. Mutants of ced-1, a homolog of Draper and MEGF10, display defects in both events. One model is that those events could be related. But our data suggest that they are actually separable. CED-1 functions in the muscle-type engulfing cells in both events and is enriched in muscle protrusions in close contact with axon debris and regenerating axons. Its two functions occur through distinct biochemical mechanisms; extracellular domain-mediated adhesion for regeneration and extracellular domain binding-induced intracellular domain signaling for debris remoNature communicationsEngulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1.PMC6242819R01 GM098026R01 GM111320Hsieh YWZou YWu YCSuzuki NChiu HChuang CFChang CfalseEngulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1.Two important biological events happen coincidently soon after nerve injury in the peripheral nervous system in C. elegans: removal of axon debris and initiation of axon regeneration. But, it is not known how these two events are co-regulated. Mutants of ced-1, a homolog of Draper and MEGF10, display defects in both events. One model is that those events could be related. But our data suggest that they are actually separable. CED-1 functions in the muscle-type engulfing cells in both events and is enriched in muscle protrusions in close contact with axon debris and regenerating axons. Its two functions occur through distinct biochemical mechanisms; extracellular domain-mediated adhesion for regeneration and extracellular domain binding-induced intracellular domain signaling for debris remo2018-01-01T00:00:00Z2018 Nov2025-04-04T08:41:18.228Z2019-03-27T00:08:32ZS-EPMC62428193045183510.1038/s41467-018-07291-x