{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dugas LR"],"funding":["U.S. Department of Veterans Affairs (VA)","BLRD VA","U.S. Department of Health & Human Services | National Institutes of Health","NIDDK NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health (NIH)","U.S. Department of Veterans Affairs"],"pagination":["17135"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6244201"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m2) and 50% obese (BMI ≥ 30 kg/m2)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of short chain fatty acids (SCFAs) with obesity. Ghanaians consumed significantly more dietary fiber, had greater microbial alpha-diversity, different beta-diversity, and had a greater concentration of total fecal SCFAs (p-value < 0.002). Lean Ghanaians had significantly greater network density, connectivity and stability than either obese Ghanaians, or lean and obese US participants (false discovery rate (FDR) corrected p-value ≤ 0.01). Bacteroides uniformis was significantly more abundant in lean women, irrespective of"],"journal":["Scientific reports"],"pubmed_title":["Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women."],"pmcid":["PMC6244201"],"funding_grant_id":["R01 DK111848","R01 DK090360","1I01BX003382","R01 DK105118","R01-DK111848","080763","R01-Dk104927","I01 BX003382","R01-DK080763","R01 DK080763","R01 DK104927"],"pubmed_authors":["Priyadarshini M","Nelson D","Dugas LR","Dong Q","Gilbert JA","Fei N","Bernabe BP","Toh EC","Layden BT","Brown L","Kliethermes S","Gottel N","Luke A","Plange-Rhule J","Gao X","Park SJ","Sun J"],"additional_accession":[]},"is_claimable":false,"name":"Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women.","description":"We compared the gut microbial populations in 100 women, from rural Ghana and urban US [50% lean (BMI < 25 kg/m2) and 50% obese (BMI ≥ 30 kg/m2)] to examine the ecological co-occurrence network topology of the gut microbiota as well as the relationship of short chain fatty acids (SCFAs) with obesity. Ghanaians consumed significantly more dietary fiber, had greater microbial alpha-diversity, different beta-diversity, and had a greater concentration of total fecal SCFAs (p-value < 0.002). Lean Ghanaians had significantly greater network density, connectivity and stability than either obese Ghanaians, or lean and obese US participants (false discovery rate (FDR) corrected p-value ≤ 0.01). Bacteroides uniformis was significantly more abundant in lean women, irrespective of","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-07-16T13:22:57.412Z","creation":"2025-05-31T23:30:23.135Z"},"accession":"S-EPMC6244201","cross_references":{"pubmed":["30459320"],"doi":["10.1038/s41598-018-35230-9"]}}