biostudies-literatureGranot-Hershkovitz ENHLBI NIH HHSNIH HHS1848-1858https://www.ebi.ac.uk/biostudies/studies/S-EPMC6244281biostudies-literatureUnknown26(12)Genetic studies in isolated populations often increase power for identifying loci associated with complex diseases and traits. We present here the Kibbutzim Family Study (KFS), aimed at investigating the genetic basis of cardiometabolic traits in extended Israeli families characterized by long-term social stability and a homogeneous environment. Extensive information on cardiometabolic traits, as well as genome-wide genotypes, were collected on 901 individuals. We observed that most KFS participants were of Ashkenazi Jewish (AJ) genetic origin, confirmed a recent severe bottleneck in the AJ recent history, and detected a subtle within-AJ population structure. Focusing on genetic variants relatively common in the KFS but very rare in Europeans, we observed that AJ-enriched variants appear iEuropean journal of human genetics : EJHGA study of Kibbutzim in Israel reveals risk factors for cardiometabolic traits and subtle population structure.PMC6244281S10 OD018522R01 HL088884Liu JCarmi SRodriguez-Murillo LKarasik DDorajoo RGranot-Hershkovitz EHochner HSewda APeter IFriedlander YfalseA study of Kibbutzim in Israel reveals risk factors for cardiometabolic traits and subtle population structure.Genetic studies in isolated populations often increase power for identifying loci associated with complex diseases and traits. We present here the Kibbutzim Family Study (KFS), aimed at investigating the genetic basis of cardiometabolic traits in extended Israeli families characterized by long-term social stability and a homogeneous environment. Extensive information on cardiometabolic traits, as well as genome-wide genotypes, were collected on 901 individuals. We observed that most KFS participants were of Ashkenazi Jewish (AJ) genetic origin, confirmed a recent severe bottleneck in the AJ recent history, and detected a subtle within-AJ population structure. Focusing on genetic variants relatively common in the KFS but very rare in Europeans, we observed that AJ-enriched variants appear i2018-01-01T00:00:00Z2018 Dec2026-05-04T12:01:36.884Z2021-02-20T09:24:06ZS-EPMC62442813010828310.1038/s41431-018-0230-3