biostudies-literatureUnknown9Sirri R<h4>Background</h4>Supplementing farm animals diet with functional ingredients may improve the nutritional quality of meat products. Diet composition has been also demonstrated to influence the gene expression with effect on biological processes and pathways. However, the knowledge on the effect of nutrients at the molecular level is scant. In particular, studies on the effects of antioxidants and polyphenols dietary supplementation have been investigated mainly in rodents, and only scarcely in farm animals so far. RNA-Seq with next-generation sequencing is increasingly the method of choice for studying changes in the transcriptome and it has been recently employed also in pig nutrigenomics studies to identify diet-induced changes in gene expression. The present study aimed to investigate Journal of animal science and biotechnology81https://www.ebi.ac.uk/biostudies/studies/S-EPMC6245756biostudies-literatureEffect of diets supplemented with linseed alone or combined with vitamin E and selenium or with plant extracts, on <i>Longissimus thoracis</i> transcriptome in growing-finishing Italian Large White pigs.PMC6245756Sami DDavoli RGiannini GZappaterra MVitali MSirri RLo Fiego DPZambonelli PfalseEffect of diets supplemented with linseed alone or combined with vitamin E and selenium or with plant extracts, on <i>Longissimus thoracis</i> transcriptome in growing-finishing Italian Large White pigs.<h4>Background</h4>Supplementing farm animals diet with functional ingredients may improve the nutritional quality of meat products. Diet composition has been also demonstrated to influence the gene expression with effect on biological processes and pathways. However, the knowledge on the effect of nutrients at the molecular level is scant. In particular, studies on the effects of antioxidants and polyphenols dietary supplementation have been investigated mainly in rodents, and only scarcely in farm animals so far. RNA-Seq with next-generation sequencing is increasingly the method of choice for studying changes in the transcriptome and it has been recently employed also in pig nutrigenomics studies to identify diet-induced changes in gene expression. The present study aimed to investigate 2018-01-01T00:00:00Z20182026-05-06T01:42:11.281Z2019-03-27T00:09:52ZS-EPMC62457563047976510.1186/s40104-018-0297-2