{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pirozzi CS"],"funding":["NIEHS NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","Foundation for the National Institutes of Health","National Institutes of Health","NIH HHS"],"pagination":["223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6245799"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>The identification of smoking-related lung disease in current and former smokers with normal FEV<sub>1</sub> is complex, leading to debate regarding using a ratio of forced expiratory volume in 1 s to forced vital capacity (FEV<sub>1</sub>/FVC) of less than 0.70 versus the predicted lower limit of normal (LLN) for diagnosis of airflow obstruction. We hypothesized that the discordant group of ever-smokers with FEV<sub>1</sub>/FVC between the LLN and 0.70 is heterogeneous, and aimed to characterize the burden of smoking-related lung disease in this group.<h4>Methods</h4>We compared spirometry, chest CT characteristics, and symptoms between 161 ever-smokers in the discordant group and 940 ever-smokers and 190 never-smokers with normal FEV<sub>1</sub> and FEV<sub>1</sub>/FVC"],"journal":["Respiratory research"],"pubmed_title":["Heterogeneous burden of lung disease in smokers with borderline airflow obstruction."],"pmcid":["PMC6245799"],"funding_grant_id":["P30 ES005605","U01 HL137880","HHSN268200900015C","HHSN268200900016C","HHSN268200900017C","HHSN268200900019C","U01 HL128952","R01 HL122438","K24 HL138188","HHSN268200900020C","K23 HL130627","HHSN268200900013C","HHSN268200900014C","K24 HL137013","HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C HHSN268200900019C, HHSN268200900020C","P30 ES006694"],"pubmed_authors":["Krishnan JA","Murray S","Han MLK","Hansel NN","Anderson WH","Kleerup EC","Oelsner EC","Bowler RP","Putcha N","Alexis NE","Christenson SA","Comellas AP","Carretta EE","Graham Barr R","Doerschuk CM","Cooper CB","Newell JD","Lazarus SC","Woodruff PG","Couper DJ","Freeman CM","Tashkin DP","Michael Wells J","Quibrera PM","Scholand MB","O'Neal WK","Han MK","Croxton T","Postow L","Paine R","Kanner RE","Criner GJ","Hoffman EA","LaVange LM","NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS)","Hastie AT","Martinez FJ","Boucher RC","Gu T","Curtis JL","Bleecker ER","Wise RA","Pirozzi CS","Ortega VE","Meyers DA","Barjaktarevic I","Crystal RG","Dransfield MT","Rennard SI","Kaner RJ","Martinez CH"],"additional_accession":[]},"is_claimable":false,"name":"Heterogeneous burden of lung disease in smokers with borderline airflow obstruction.","description":"<h4>Background</h4>The identification of smoking-related lung disease in current and former smokers with normal FEV<sub>1</sub> is complex, leading to debate regarding using a ratio of forced expiratory volume in 1 s to forced vital capacity (FEV<sub>1</sub>/FVC) of less than 0.70 versus the predicted lower limit of normal (LLN) for diagnosis of airflow obstruction. We hypothesized that the discordant group of ever-smokers with FEV<sub>1</sub>/FVC between the LLN and 0.70 is heterogeneous, and aimed to characterize the burden of smoking-related lung disease in this group.<h4>Methods</h4>We compared spirometry, chest CT characteristics, and symptoms between 161 ever-smokers in the discordant group and 940 ever-smokers and 190 never-smokers with normal FEV<sub>1</sub> and FEV<sub>1</sub>/FVC","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-05-05T22:51:52.469Z","creation":"2019-03-27T00:08:58Z"},"accession":"S-EPMC6245799","cross_references":{"pubmed":["30454050"],"doi":["10.1186/s12931-018-0911-z"]}}