biostudies-literaturePirozzi CSNIEHS NIH HHSNHLBI NIH HHSNational Heart, Lung, and Blood InstituteFoundation for the National Institutes of HealthNational Institutes of HealthNIH HHS223https://www.ebi.ac.uk/biostudies/studies/S-EPMC6245799biostudies-literatureUnknown19(1)<h4>Background</h4>The identification of smoking-related lung disease in current and former smokers with normal FEV₁ is complex, leading to debate regarding using a ratio of forced expiratory volume in 1 s to forced vital capacity (FEV₁/FVC) of less than 0.70 versus the predicted lower limit of normal (LLN) for diagnosis of airflow obstruction. We hypothesized that the discordant group of ever-smokers with FEV₁/FVC between the LLN and 0.70 is heterogeneous, and aimed to characterize the burden of smoking-related lung disease in this group.<h4>Methods</h4>We compared spirometry, chest CT characteristics, and symptoms between 161 ever-smokers in the discordant group and 940 ever-smokers and 190 never-smokers with normal FEV₁ and FEV₁/FVCRespiratory researchHeterogeneous burden of lung disease in smokers with borderline airflow obstruction.PMC6245799P30 ES005605U01 HL137880HHSN268200900015CHHSN268200900016CHHSN268200900017CHHSN268200900019CU01 HL128952R01 HL122438K24 HL138188HHSN268200900020CK23 HL130627HHSN268200900013CHHSN268200900014CK24 HL137013HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C HHSN268200900019C, HHSN268200900020CP30 ES006694Krishnan JAMurray SHan MLKHansel NNAnderson WHKleerup ECOelsner ECBowler RPPutcha NAlexis NEChristenson SAComellas APCarretta EEGraham Barr RDoerschuk CMCooper CBNewell JDLazarus SCWoodruff PGCouper DJFreeman CMTashkin DPMichael Wells JQuibrera PMScholand MBO'Neal WKHan MKCroxton TPostow LPaine RKanner RECriner GJHoffman EALaVange LMNHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS)Hastie ATMartinez FJBoucher RCGu TCurtis JLBleecker ERWise RAPirozzi CSOrtega VEMeyers DABarjaktarevic ICrystal RGDransfield MTRennard SIKaner RJMartinez CHfalseHeterogeneous burden of lung disease in smokers with borderline airflow obstruction.<h4>Background</h4>The identification of smoking-related lung disease in current and former smokers with normal FEV₁ is complex, leading to debate regarding using a ratio of forced expiratory volume in 1 s to forced vital capacity (FEV₁/FVC) of less than 0.70 versus the predicted lower limit of normal (LLN) for diagnosis of airflow obstruction. We hypothesized that the discordant group of ever-smokers with FEV₁/FVC between the LLN and 0.70 is heterogeneous, and aimed to characterize the burden of smoking-related lung disease in this group.<h4>Methods</h4>We compared spirometry, chest CT characteristics, and symptoms between 161 ever-smokers in the discordant group and 940 ever-smokers and 190 never-smokers with normal FEV₁ and FEV₁/FVC2018-01-01T00:00:00Z2018 Nov2026-05-05T22:51:52.469Z2019-03-27T00:08:58ZS-EPMC62457993045405010.1186/s12931-018-0911-z