{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kauffman KD"],"funding":["HHS | NIH | National Institute of Allergy and Infectious Diseases"],"pagination":["e00431-18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6246904"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["86(12)"],"pubmed_abstract":["Mucosal-associated invariant T cells (MAITs) are positioned in airways and may be important in the pulmonary cellular immune response against <i>Mycobacterium tuberculosis</i> infection, particularly prior to priming of peptide-specific T cells. Accordingly, there is interest in the possibility that boosting MAITs through tuberculosis (TB) vaccination may enhance protection, but MAIT responses in the lungs during tuberculosis are poorly understood. In this study, we compared pulmonary MAIT and peptide-specific CD4 T cell responses in <i>M. tuberculosis</i>-infected rhesus macaques using 5-OP-RU-loaded MR-1 tetramers and intracellular cytokine staining of CD4 T cells following restimulation with an <i>M. tuberculosis</i>-derived epitope megapool (MTB300), respectively. Two of four animals s"],"journal":["Infection and immunity"],"pubmed_title":["Limited Pulmonary Mucosal-Associated Invariant T Cell Accumulation and Activation during Mycobacterium tuberculosis Infection in Rhesus Macaques."],"pmcid":["PMC6246904"],"funding_grant_id":["Intramural Research Program ZIAAI001171"],"pubmed_authors":["Hoft SG","Arlehamn CSL","Sette A","Sakai S","Wilder-Kofie T","Kauffman KD","Barber DL","Sallin MA","Moore R","Moore IN"],"additional_accession":[]},"is_claimable":false,"name":"Limited Pulmonary Mucosal-Associated Invariant T Cell Accumulation and Activation during Mycobacterium tuberculosis Infection in Rhesus Macaques.","description":"Mucosal-associated invariant T cells (MAITs) are positioned in airways and may be important in the pulmonary cellular immune response against <i>Mycobacterium tuberculosis</i> infection, particularly prior to priming of peptide-specific T cells. Accordingly, there is interest in the possibility that boosting MAITs through tuberculosis (TB) vaccination may enhance protection, but MAIT responses in the lungs during tuberculosis are poorly understood. In this study, we compared pulmonary MAIT and peptide-specific CD4 T cell responses in <i>M. tuberculosis</i>-infected rhesus macaques using 5-OP-RU-loaded MR-1 tetramers and intracellular cytokine staining of CD4 T cells following restimulation with an <i>M. tuberculosis</i>-derived epitope megapool (MTB300), respectively. Two of four animals s","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2026-07-16T08:01:12.56Z","creation":"2019-06-06T23:22:25Z"},"accession":"S-EPMC6246904","cross_references":{"pubmed":["30201702"],"doi":["10.1128/IAI.00431-18","10.1128/iai.00431-18"]}}