{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Alimoradi H"],"pubmed_abstract":["<h4>Purpose</h4>Anticancer drug delivery systems are often limited by hurdles, such as off-target distribution, slow cellular internalization, limited lysosomal escape, and drug resistance. To overcome these limitations, we have developed a stable nitric oxide (NO)-releasing nanoparticle (polystyrene-maleic acid [SMA]-<i>tert</i>-dodecane S-nitrosothiol [tDodSNO]) with the aim of enhancing the anticancer properties of doxorubicin (Dox) and a Dox-loaded nanoparticle (SMA-Dox) carrier.<h4>Materials and methods</h4>Effects of SMA-tDodSNO and/or in combination with Dox or SMA-Dox on cell viability, apoptosis, mitochondrial membrane potential, lysosomal membrane permeability, tumor tissue, and tumor growth were studied using in vitro and in vivo model of triple-negative breast cancer (TNBC). In"],"journal":["International journal of nanomedicine"],"pagination":["7771-7787"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6251458"],"repository":["biostudies-literature"],"pubmed_title":["Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity."],"pmcid":["PMC6251458"],"pubmed_authors":["Barzegar-Fallah A","Alshaibani L","Alimoradi H","Greish K","Pittala V"],"additional_accession":[]},"is_claimable":false,"name":"Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity.","description":"<h4>Purpose</h4>Anticancer drug delivery systems are often limited by hurdles, such as off-target distribution, slow cellular internalization, limited lysosomal escape, and drug resistance. To overcome these limitations, we have developed a stable nitric oxide (NO)-releasing nanoparticle (polystyrene-maleic acid [SMA]-<i>tert</i>-dodecane S-nitrosothiol [tDodSNO]) with the aim of enhancing the anticancer properties of doxorubicin (Dox) and a Dox-loaded nanoparticle (SMA-Dox) carrier.<h4>Materials and methods</h4>Effects of SMA-tDodSNO and/or in combination with Dox or SMA-Dox on cell viability, apoptosis, mitochondrial membrane potential, lysosomal membrane permeability, tumor tissue, and tumor growth were studied using in vitro and in vivo model of triple-negative breast cancer (TNBC). In","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-05T12:59:55.512Z","creation":"2019-03-27T00:11:27Z"},"accession":"S-EPMC6251458","cross_references":{"pubmed":["30538458"],"doi":["10.2147/IJN.S187089"]}}