biostudies-literatureLansky AJDutch Heart Foundation1687-1697https://www.ebi.ac.uk/biostudies/studies/S-EPMC6251670biostudies-literatureUnknown39(19)Surgical and catheter-based cardiovascular procedures and adjunctive pharmacology have an inherent risk of neurological complications. The current diversity of neurological endpoint definitions and ascertainment methods in clinical trials has led to uncertainties in the neurological risk attributable to cardiovascular procedures and inconsistent evaluation of therapies intended to prevent or mitigate neurological injury. Benefit-risk assessment of such procedures should be on the basis of an evaluation of well-defined neurological outcomes that are ascertained with consistent methods and capture the full spectrum of neurovascular injury and its clinical effect. The Neurologic Academic Research Consortium is an international collaboration intended to establish consensus on the definition, cEuropean heart journalProposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative.PMC62516702010T075Browndyke JMesse SRBrickman AMvan Es GAParides MKKodali SDwyer MPopma JGress DAkar JHolmes DNg VGScala Moy CBilello MMack MMoses JPetersen NHSchofer JBart van der Worp HLansky AJKappetein APVirmani RZivadinov RPietras CGLinke AGreer DFurie KLVoros SMcFadden EBaumbach AForrest JKLazar RMKrucoff MWKapadia SCutlip DEPrendergast BAbrams KJfalseProposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative.Surgical and catheter-based cardiovascular procedures and adjunctive pharmacology have an inherent risk of neurological complications. The current diversity of neurological endpoint definitions and ascertainment methods in clinical trials has led to uncertainties in the neurological risk attributable to cardiovascular procedures and inconsistent evaluation of therapies intended to prevent or mitigate neurological injury. Benefit-risk assessment of such procedures should be on the basis of an evaluation of well-defined neurological outcomes that are ascertained with consistent methods and capture the full spectrum of neurovascular injury and its clinical effect. The Neurologic Academic Research Consortium is an international collaboration intended to establish consensus on the definition, c2018-01-01T00:00:00Z2018 May2026-05-05T22:23:25.885Z2019-06-06T23:04:32ZS-EPMC62516702817152210.1093/eurheartj/ehx037