{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chang SH"],"funding":["Ministry of Science and Technology"],"pagination":["5389-5401"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6255702"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["69(22)"],"pubmed_abstract":["As key mediators linking developmental processes with plant immunity, TCP (TEOSINTE-BRANCHED, CYCLOIDEA, PROLIFERATION FACTOR 1 and 2) transcription factors have been increasingly shown to be targets of pathogenic effectors. We report here that TB/CYC (TEOSINTE-BRANCHED/CYCLOIDEA)-TCPs are destabilized by phytoplasma SAP11 effectors, leading to the proliferation of axillary meristems. Although a high degree of sequence diversity was observed among putative SAP11 effectors identified from evolutionarily distinct clusters of phytoplasmas, these effectors acquired fundamental activity in destabilizing TB/CYC-TCPs. In addition, we demonstrate that miR156/SPLs and miR172/AP2 modules, which represent key regulatory hubs involved in plant phase transition, were modulated by Aster Yellows phytoplasma strain Witches' Broom (AY-WB) protein SAP11. A late-flowering phenotype with significant changes in the expression of flowering-related genes was observed in transgenic Arabidopsis plants expressing SAP11AYWB. These morphological and molecular alterations were correlated with the ability of SAP11 effectors to destabilize CIN (CINCINNATA)-TCPs. Although not all putative SAP11 effectors display broad-spectrum activities in modulating morphological and physiological changes in host plants, they serve as core virulence factors responsible for the witches' broom symptom caused by phytoplasmas."],"journal":["Journal of experimental botany"],"pubmed_title":["Alterations of plant architecture and phase transition by the phytoplasma virulence factor SAP11."],"pmcid":["PMC6255702"],"funding_grant_id":["MOST-106-2811-B-005-006","MOST-105-2911-I-005-301","MOST-105-2321-B-005-003","MOST-105-2628-B-005-001"],"pubmed_authors":["Tsai MC","Yang JY","Jiang SY","Liu RC","Tan CM","Lin TH","Chang SH","Wu CT","Su LW"],"additional_accession":[]},"is_claimable":false,"name":"Alterations of plant architecture and phase transition by the phytoplasma virulence factor SAP11.","description":"As key mediators linking developmental processes with plant immunity, TCP (TEOSINTE-BRANCHED, CYCLOIDEA, PROLIFERATION FACTOR 1 and 2) transcription factors have been increasingly shown to be targets of pathogenic effectors. We report here that TB/CYC (TEOSINTE-BRANCHED/CYCLOIDEA)-TCPs are destabilized by phytoplasma SAP11 effectors, leading to the proliferation of axillary meristems. Although a high degree of sequence diversity was observed among putative SAP11 effectors identified from evolutionarily distinct clusters of phytoplasmas, these effectors acquired fundamental activity in destabilizing TB/CYC-TCPs. In addition, we demonstrate that miR156/SPLs and miR172/AP2 modules, which represent key regulatory hubs involved in plant phase transition, were modulated by Aster Yellows phytoplasma strain Witches' Broom (AY-WB) protein SAP11. A late-flowering phenotype with significant changes in the expression of flowering-related genes was observed in transgenic Arabidopsis plants expressing SAP11AYWB. These morphological and molecular alterations were correlated with the ability of SAP11 effectors to destabilize CIN (CINCINNATA)-TCPs. Although not all putative SAP11 effectors display broad-spectrum activities in modulating morphological and physiological changes in host plants, they serve as core virulence factors responsible for the witches' broom symptom caused by phytoplasmas.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2024-10-15T00:57:45.796Z","creation":"2019-03-27T00:11:02Z"},"accession":"S-EPMC6255702","cross_references":{"pubmed":["30165491"],"doi":["10.1093/jxb/ery318"]}}