{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Panupattanapong S"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","Agency for Healthcare Research and Quality","AHRQ HHS","National Cancer Institute","NCI NIH HHS"],"pagination":["2067-2076"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6258356"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["70(12)"],"pubmed_abstract":["OBJECTIVE:The incidence and prevalence of granulomatosis with polyangiitis (GPA) in the US is not well characterized. Owing to its rarity, outcomes data in pediatric-onset GPA are also lacking. The aims of this study were to describe the epidemiology of GPA and outcomes in GPA patients in the US, and to compare outcomes between pediatric and working-age adult patients. METHODS:A retrospective cohort study using the 2006-2014 Truven Health Analytics MarketScan Commercial Claims and Encounters Database was conducted. The incidence and prevalence rates of pediatric and adult GPA (age <65 years) were calculated. Outcomes among the 2 age groups were analyzed. RESULTS:A total of 5,562 cases of GPA were identified, of which 214 (3.8%) were pediatric onset and 5,348 (96.2%) were adult onset. The i"],"journal":["Arthritis & rheumatology (Hoboken, N.J.)"],"pubmed_title":["Epidemiology and Outcomes of Granulomatosis With Polyangiitis in Pediatric and Working-Age Adult Populations In the United States: Analysis of a Large National Claims Database."],"pmcid":["PMC6258356"],"funding_grant_id":["R24 HS19455","UL1 TR002345","R24 HS019455","KM1 CA156708","KM1CA156708","UL1 TR000448"],"pubmed_authors":["Hartman ME","Panupattanapong S","Stwalley DL","Olsen MA","White AJ","French AR"],"additional_accession":[]},"is_claimable":false,"name":"Epidemiology and Outcomes of Granulomatosis With Polyangiitis in Pediatric and Working-Age Adult Populations In the United States: Analysis of a Large National Claims Database.","description":"OBJECTIVE:The incidence and prevalence of granulomatosis with polyangiitis (GPA) in the US is not well characterized. Owing to its rarity, outcomes data in pediatric-onset GPA are also lacking. The aims of this study were to describe the epidemiology of GPA and outcomes in GPA patients in the US, and to compare outcomes between pediatric and working-age adult patients. METHODS:A retrospective cohort study using the 2006-2014 Truven Health Analytics MarketScan Commercial Claims and Encounters Database was conducted. The incidence and prevalence rates of pediatric and adult GPA (age <65 years) were calculated. Outcomes among the 2 age groups were analyzed. RESULTS:A total of 5,562 cases of GPA were identified, of which 214 (3.8%) were pediatric onset and 5,348 (96.2%) were adult onset. The i","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-05T09:52:11.514Z","creation":"2020-05-21T20:17:39Z"},"accession":"S-EPMC6258356","cross_references":{"pubmed":["29806148"],"doi":["10.1002/art.40577"]}}