{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["MacPherson P"],"funding":["European & Developing Countries Clinical Trials Partnership (EDCTP)","Department for International Development, UK Government","Medical Research Council","Wellcome Trust"],"pagination":["61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6259593"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3"],"pubmed_abstract":["<b>Background:</b> Adults seeking diagnosis and treatment for tuberculosis (TB) and HIV in low-resource settings face considerable barriers and have high pre-treatment mortality. Efforts to improve access to prompt TB treatment have been hampered by limitations in TB diagnostics, with considerable uncertainty about how available and new tests can best be implemented. <b>Design and methods:</b> The PROSPECT Study is an open, three-arm pragmatic randomised study that will investigate the effectiveness and cost-effectiveness of optimised HIV and TB diagnosis and linkage to care interventions in reducing time to TB diagnosis and prevalence of undiagnosed TB and HIV in primary care in Blantyre, Malawi. Participants (≥ 18 years) attending a primary care clinic with TB symptoms (cough of any dura"],"journal":["Wellcome open research"],"pubmed_title":["Design and protocol for a pragmatic randomised study to optimise screening, prevention and care for tuberculosis and HIV in Malawi (PROSPECT Study)."],"pmcid":["PMC6259593"],"funding_grant_id":["200901","MR/K012126/1","200901/Z/16/Z","206575/Z/17/Z","206575"],"pubmed_authors":["Webb EL","Lalloo DG","Corbett EL","Pai M","Squire B","Nliwasa M","Maheswaran H","Joekes E","Phiri D","MacPherson P"],"additional_accession":[]},"is_claimable":false,"name":"Design and protocol for a pragmatic randomised study to optimise screening, prevention and care for tuberculosis and HIV in Malawi (PROSPECT Study).","description":"<b>Background:</b> Adults seeking diagnosis and treatment for tuberculosis (TB) and HIV in low-resource settings face considerable barriers and have high pre-treatment mortality. Efforts to improve access to prompt TB treatment have been hampered by limitations in TB diagnostics, with considerable uncertainty about how available and new tests can best be implemented. <b>Design and methods:</b> The PROSPECT Study is an open, three-arm pragmatic randomised study that will investigate the effectiveness and cost-effectiveness of optimised HIV and TB diagnosis and linkage to care interventions in reducing time to TB diagnosis and prevalence of undiagnosed TB and HIV in primary care in Blantyre, Malawi. Participants (≥ 18 years) attending a primary care clinic with TB symptoms (cough of any dura","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-04-08T04:34:14.554Z","creation":"2019-03-27T00:12:08Z"},"accession":"S-EPMC6259593","cross_references":{"pubmed":["30542662"],"doi":["10.12688/wellcomeopenres.14598.3"]}}