{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wilson D"],"funding":["Versus Arthritis","Medical Research Council","National Institute for Health Research (NIHR)","Biotechnology and Biological Sciences Research Council"],"pagination":["830"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6260758"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Objectives
To describe the difficulties of obtaining muscle samples using a Bergstrom needle technique in a frail older adult population. The data were obtained from a study primarily investigating immunosenescence in frailty. An intended research technique was skeletal muscle biopsy in a small subset of participants to investigate muscle morphology and local inflammatory factors.Results
Forty healthy older adults and 37 frail older adults were considered for a Bergstrom needle muscle biopsy. Of these, 17.5% of healthy older adults and 94.6% of the frail older adults had single or multiple participant factors resulting in a contra-indication to muscle biopsy. 40.7% of healthy older female participants were at risk of a failed muscle biopsy due to low muscle mass. Considerin"],"journal":["BMC research notes"],"pubmed_title":["The challenges of muscle biopsy in a community based geriatric population."],"pmcid":["PMC6260758"],"funding_grant_id":["1511471","BB/N018214/1","MR/K00414X/1","MR/L008335/1","MR/P021220/1","CL-2017-09-003"],"pubmed_authors":["Wilson D","Breen L","Lord JM","Sapey E"],"additional_accession":[]},"is_claimable":false,"name":"The challenges of muscle biopsy in a community based geriatric population.","description":"Objectives
To describe the difficulties of obtaining muscle samples using a Bergstrom needle technique in a frail older adult population. The data were obtained from a study primarily investigating immunosenescence in frailty. An intended research technique was skeletal muscle biopsy in a small subset of participants to investigate muscle morphology and local inflammatory factors.Results
Forty healthy older adults and 37 frail older adults were considered for a Bergstrom needle muscle biopsy. Of these, 17.5% of healthy older adults and 94.6% of the frail older adults had single or multiple participant factors resulting in a contra-indication to muscle biopsy. 40.7% of healthy older female participants were at risk of a failed muscle biopsy due to low muscle mass. Considerin","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-07-16T08:09:10.427Z","creation":"2026-07-09T10:49:03.996Z"},"accession":"S-EPMC6260758","cross_references":{"pubmed":["30477571"],"doi":["10.1186/s13104-018-3947-8"]}}