biostudies-literatureWilson DVersus ArthritisMedical Research CouncilNational Institute for Health Research (NIHR)Biotechnology and Biological Sciences Research Council830https://www.ebi.ac.uk/biostudies/studies/S-EPMC6260758biostudies-literatureUnknown11(1)<h4>Objectives</h4>To describe the difficulties of obtaining muscle samples using a Bergstrom needle technique in a frail older adult population. The data were obtained from a study primarily investigating immunosenescence in frailty. An intended research technique was skeletal muscle biopsy in a small subset of participants to investigate muscle morphology and local inflammatory factors.<h4>Results</h4>Forty healthy older adults and 37 frail older adults were considered for a Bergstrom needle muscle biopsy. Of these, 17.5% of healthy older adults and 94.6% of the frail older adults had single or multiple participant factors resulting in a contra-indication to muscle biopsy. 40.7% of healthy older female participants were at risk of a failed muscle biopsy due to low muscle mass. ConsiderinBMC research notesThe challenges of muscle biopsy in a community based geriatric population.PMC62607581511471BB/N018214/1MR/K00414X/1MR/L008335/1MR/P021220/1CL-2017-09-003Wilson DBreen LLord JMSapey EfalseThe challenges of muscle biopsy in a community based geriatric population.<h4>Objectives</h4>To describe the difficulties of obtaining muscle samples using a Bergstrom needle technique in a frail older adult population. The data were obtained from a study primarily investigating immunosenescence in frailty. An intended research technique was skeletal muscle biopsy in a small subset of participants to investigate muscle morphology and local inflammatory factors.<h4>Results</h4>Forty healthy older adults and 37 frail older adults were considered for a Bergstrom needle muscle biopsy. Of these, 17.5% of healthy older adults and 94.6% of the frail older adults had single or multiple participant factors resulting in a contra-indication to muscle biopsy. 40.7% of healthy older female participants were at risk of a failed muscle biopsy due to low muscle mass. Considerin2018-01-01T00:00:00Z2018 Nov2026-07-16T08:09:10.427Z2026-07-09T10:49:03.996ZS-EPMC62607583047757110.1186/s13104-018-3947-8