{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Underwood AP"],"funding":["National Health and Medical Research Council","University of New South Wales"],"pagination":["E659"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6266478"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(11)"],"pubmed_abstract":["Despite recent advances in curative therapy, hepatitis C virus (HCV) still remains a global threat. In order to achieve global elimination, a prophylactic vaccine should be considered high priority. Previous immunogens used to induce broad neutralising antibodies (BnAbs) have been met with limited success. To improve immunogen design, factors associated with the early development of BnAbs in natural infection must first be understood. In this study, 43 subjects identified with acute HCV were analysed longitudinally using a panel of heterogeneous HCV pseudoparticles (HCVpp), to understand the emergence of BnAbs. Compared to those infected with a single genotype, early BnAb development was associated with subjects co-infected with at least 2 HCV subtypes during acute infection. In those that"],"journal":["Viruses"],"pubmed_title":["Understanding the Determinants of BnAb Induction in Acute HCV Infection."],"pmcid":["PMC6266478"],"funding_grant_id":["630483","1053206","510488"],"pubmed_authors":["Walker MR","Brasher NA","Eltahla AA","Maher L","Luciani F","Bull RA","Underwood AP","Lloyd AR"],"additional_accession":[]},"is_claimable":false,"name":"Understanding the Determinants of BnAb Induction in Acute HCV Infection.","description":"Despite recent advances in curative therapy, hepatitis C virus (HCV) still remains a global threat. In order to achieve global elimination, a prophylactic vaccine should be considered high priority. Previous immunogens used to induce broad neutralising antibodies (BnAbs) have been met with limited success. To improve immunogen design, factors associated with the early development of BnAbs in natural infection must first be understood. In this study, 43 subjects identified with acute HCV were analysed longitudinally using a panel of heterogeneous HCV pseudoparticles (HCVpp), to understand the emergence of BnAbs. Compared to those infected with a single genotype, early BnAb development was associated with subjects co-infected with at least 2 HCV subtypes during acute infection. In those that","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2025-04-04T10:02:36.103Z","creation":"2019-03-27T00:11:35Z"},"accession":"S-EPMC6266478","cross_references":{"pubmed":["30469363"],"doi":["10.3390/v10110659"]}}