{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(11)"],"submitter":["Yang LH"],"pubmed_abstract":["To investigate structurally novel and anti-neuroinflammatory natural compounds from marine-derived microorganisms, the secondary metabolites of <i>Aspergillus terreus</i> Y10, a fungus separated from the sediment of the coast in the South China Sea, were studied. Three new compounds (<b>2</b>⁻<b>4</b>), with novel open-ring butenolide skeletons, were isolated from the ethyl acetate extract of the culture medium. In addition, a typical new butenolide, asperteretal F (<b>1</b>), was found to dose-dependently inhibit tumor necrosis factor (TNF-α) generation with an IC<sub>50</sub> of 7.6 μg/mL. The present study shows the existence of open-ring butenolides, and suggests that butenolides such as asperteretal F (<b>1</b>) are a promising new anti-neuroinflammatroy candidate for neurodegenerativ"],"journal":["Marine drugs"],"pagination":["E428"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6267272"],"repository":["biostudies-literature"],"pubmed_title":["Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus <i>Aspergillus terreus</i> Y10."],"pmcid":["PMC6267272"],"pubmed_authors":["Qiu YK","Tang BW","Wu Z","Chen JW","Yang LH","Ou-Yang H","Yan X","Fang MJ"],"additional_accession":[]},"is_claimable":false,"name":"Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus <i>Aspergillus terreus</i> Y10.","description":"To investigate structurally novel and anti-neuroinflammatory natural compounds from marine-derived microorganisms, the secondary metabolites of <i>Aspergillus terreus</i> Y10, a fungus separated from the sediment of the coast in the South China Sea, were studied. Three new compounds (<b>2</b>⁻<b>4</b>), with novel open-ring butenolide skeletons, were isolated from the ethyl acetate extract of the culture medium. In addition, a typical new butenolide, asperteretal F (<b>1</b>), was found to dose-dependently inhibit tumor necrosis factor (TNF-α) generation with an IC<sub>50</sub> of 7.6 μg/mL. The present study shows the existence of open-ring butenolides, and suggests that butenolides such as asperteretal F (<b>1</b>) are a promising new anti-neuroinflammatroy candidate for neurodegenerativ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-06-03T16:43:18.128Z","creation":"2026-05-31T03:06:35.448Z"},"accession":"S-EPMC6267272","cross_references":{"pubmed":["30400195"],"doi":["10.3390/md16110428"]}}