{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(5)"],"submitter":["Huang J"],"pubmed_abstract":["Acorns play an important role in human history and are a source of food and recipes for many cultures around the world. In this study, eleven oleanolic triterpenes, one of which was novel, were isolated from Chinese acorns (Quercus serrata var. brevipetiolata). The chemical structure of the novel triterpene, which was identified as 2α,3β,19α-trihydroxy-24-oxo-olean-12-en-28-oic acid (1), was established based on the interpretation of chemical and spectroscopic analyses, including IR, HR-ESI-MS, and NMR experiments (¹H, (13)C NMR, DEPT, ¹H-¹H COSY, HSQC, HMBC, and NOESY). All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages. Compared with the positive control drug indomethacin (IC50 = 47.4 μM), compounds 1, 3, 6"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["E669"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6272836"],"repository":["biostudies-literature"],"pubmed_title":["Anti-Inflammatory Oleanolic Triterpenes from Chinese Acorns."],"pmcid":["PMC6272836"],"pubmed_authors":["Li C","Huang J","He X","Wang X","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Anti-Inflammatory Oleanolic Triterpenes from Chinese Acorns.","description":"Acorns play an important role in human history and are a source of food and recipes for many cultures around the world. In this study, eleven oleanolic triterpenes, one of which was novel, were isolated from Chinese acorns (Quercus serrata var. brevipetiolata). The chemical structure of the novel triterpene, which was identified as 2α,3β,19α-trihydroxy-24-oxo-olean-12-en-28-oic acid (1), was established based on the interpretation of chemical and spectroscopic analyses, including IR, HR-ESI-MS, and NMR experiments (¹H, (13)C NMR, DEPT, ¹H-¹H COSY, HSQC, HMBC, and NOESY). All isolated compounds were tested for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages. Compared with the positive control drug indomethacin (IC50 = 47.4 μM), compounds 1, 3, 6","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2026-07-16T16:35:55.869Z","creation":"2019-03-26T22:31:34Z"},"accession":"S-EPMC6272836","cross_references":{"pubmed":["27213322"],"doi":["10.3390/molecules21050669"]}}