{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ko YS"],"funding":["National Research Foundation of Korea"],"pagination":["E3350"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6274837"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(11)"],"pubmed_abstract":["The cardiac glycosides oleandrin and odoroside A, polyphenolic monomer compounds extracted from <i>Nerium oleander</i>, have been found to have antitumor effects on various tumors at low doses. However, the mechanisms of anticancer effects of oleandrin and odoroside A are not well known. Therefore, in this study, we aimed to investigate the anticancer effects of oleandrin and odoroside A and their associated mechanisms in highly metastatic MDA-MB-231 breast cancer cells and radiotherapy-resistant (RT-R) MDA-MB-231 cells. Our results showed that oleandrin and odoroside A dose-dependently decreased the colony formation and the invasion of both cell lines at nanomolar ranges. Furthermore, oleandrin (50 nM) and odoroside A (100 nM) reduced octamer-binding transcription factor 3/4 (OCT3/4) and "],"journal":["International journal of molecular sciences"],"pubmed_title":["Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway."],"pmcid":["PMC6274837"],"funding_grant_id":["2015R1A1A3A04001029","2018R1A2B6001786"],"pubmed_authors":["Rugira T","Jin H","Ko YS","Kim HJ","Park SW"],"additional_accession":[]},"is_claimable":false,"name":"Oleandrin and Its Derivative Odoroside A, Both Cardiac Glycosides, Exhibit Anticancer Effects by Inhibiting Invasion via Suppressing the STAT-3 Signaling Pathway.","description":"The cardiac glycosides oleandrin and odoroside A, polyphenolic monomer compounds extracted from <i>Nerium oleander</i>, have been found to have antitumor effects on various tumors at low doses. However, the mechanisms of anticancer effects of oleandrin and odoroside A are not well known. Therefore, in this study, we aimed to investigate the anticancer effects of oleandrin and odoroside A and their associated mechanisms in highly metastatic MDA-MB-231 breast cancer cells and radiotherapy-resistant (RT-R) MDA-MB-231 cells. Our results showed that oleandrin and odoroside A dose-dependently decreased the colony formation and the invasion of both cell lines at nanomolar ranges. Furthermore, oleandrin (50 nM) and odoroside A (100 nM) reduced octamer-binding transcription factor 3/4 (OCT3/4) and ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Oct","modification":"2026-07-09T12:06:30.271Z","creation":"2025-05-18T13:33:43.949Z"},"accession":"S-EPMC6274837","cross_references":{"pubmed":["30373171"],"doi":["10.3390/ijms19113350"]}}