{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Caruso G"],"funding":["American Heart Association","National Institutes of Health","Neuropsychopharmacology Research Program 2017","NIGMS NIH HHS","National Science Foundation"],"pagination":["E3659"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6274958"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(11)"],"pubmed_abstract":["Human amylin is a 37-residue peptide hormone (hA1-37) secreted by β-cells of the pancreas and, along with insulin, is directly associated with type 2 diabetes mellitus (T2DM). Amyloid deposits within the islets of the pancreas represent a hallmark of T2DM. Additionally, amylin aggregates have been found in blood vessels and/or brain of patients with Alzheimer's disease, alone or co-deposited with β-amyloid. The purpose of this study was to investigate the neuroprotective potential of human amylin in the context of endothelial-neuronal \"cross-talk\". We initially performed dose-response experiments to examine cellular toxicity (quantified by the [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] MTT assay) of different hA17⁻29 concentrations in endothelial cells (RBE4). In the cu"],"journal":["International journal of molecular sciences"],"pubmed_title":["Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells."],"pmcid":["PMC6274958"],"funding_grant_id":["P20 GM103638","CHE-1411993","RC-06-05","P20GM103638","NFP0075515"],"pubmed_authors":["Caraci F","Fresta CG","Distefano DA","Parlascino P","Lunte SM","Caruso G","Lazzarino G"],"additional_accession":[]},"is_claimable":false,"name":"Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells.","description":"Human amylin is a 37-residue peptide hormone (hA1-37) secreted by β-cells of the pancreas and, along with insulin, is directly associated with type 2 diabetes mellitus (T2DM). Amyloid deposits within the islets of the pancreas represent a hallmark of T2DM. Additionally, amylin aggregates have been found in blood vessels and/or brain of patients with Alzheimer's disease, alone or co-deposited with β-amyloid. The purpose of this study was to investigate the neuroprotective potential of human amylin in the context of endothelial-neuronal \"cross-talk\". We initially performed dose-response experiments to examine cellular toxicity (quantified by the [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] MTT assay) of different hA17⁻29 concentrations in endothelial cells (RBE4). In the cu","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-07-16T17:25:05.376Z","creation":"2019-03-27T00:11:38Z"},"accession":"S-EPMC6274958","cross_references":{"pubmed":["30463298"],"doi":["10.3390/ijms19113659"]}}