{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li B"],"funding":["CAS Key Research Program of Frontier Sciences","National Natural Science Foundation of China","National Key Research and Development Program"],"pagination":["12118-12123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6275518"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(48)"],"pubmed_abstract":["Intracellular transport of cellular proteins and organelles is critical for establishing and maintaining intracellular organization and cell physiology. Apoptosis is a process of programmed cell death with dramatic changes in cell morphology and organization, during which signaling molecules are transported between different organelles within the cells. However, how the intracellular transport changes in cells undergoing apoptosis remains unknown. Here, we study the dynamics of intracellular transport by using the single-particle tracking method and find that both directed and diffusive motions of endocytic vesicles are accelerated in early apoptotic cells. With careful elimination of other factors involved in the intracellular transport, the reason for the acceleration is attributed to th"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Intracellular transport is accelerated in early apoptotic cells."],"pmcid":["PMC6275518"],"funding_grant_id":["11774407","QYZDB-SSW-SLH045","2016YFA0301500","11874415","11674383"],"pubmed_authors":["Dou SX","Li W","Li H","Wang PY","Li B","Ye F","Liu YR","Yuan JW"],"additional_accession":[]},"is_claimable":false,"name":"Intracellular transport is accelerated in early apoptotic cells.","description":"Intracellular transport of cellular proteins and organelles is critical for establishing and maintaining intracellular organization and cell physiology. Apoptosis is a process of programmed cell death with dramatic changes in cell morphology and organization, during which signaling molecules are transported between different organelles within the cells. However, how the intracellular transport changes in cells undergoing apoptosis remains unknown. Here, we study the dynamics of intracellular transport by using the single-particle tracking method and find that both directed and diffusive motions of endocytic vesicles are accelerated in early apoptotic cells. With careful elimination of other factors involved in the intracellular transport, the reason for the acceleration is attributed to th","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2025-05-18T13:34:25.644Z","creation":"2025-05-18T13:34:25.644Z"},"accession":"S-EPMC6275518","cross_references":{"pubmed":["30429318"],"doi":["10.1073/pnas.1810017115"]}}