{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(12)"],"submitter":["Blanco Y"],"pubmed_abstract":["High-energy ionizing radiation in the form of solar energetic particles and galactic cosmic rays is pervasive on the surface of planetary bodies with thin atmospheres or in space facilities for humans, and it may seriously affect the chemistry and the structure of organic and biological material. We used fluorescent microarray immunoassays to assess how different doses of electron and gamma radiations affect the stability of target compounds such as biological polymers and small molecules (haptens) conjugated to large proteins. The radiation effect was monitored by measuring the loss in the immunoidentification of the target due to an impaired ability of the antibodies for binding their corresponding irradiated and damaged epitopes (the part of the target molecule to which antibodies bind)"],"journal":["Astrobiology"],"pagination":["1497-1516"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6276817"],"repository":["biostudies-literature"],"pubmed_title":["Effects of Gamma and Electron Radiation on the Structural Integrity of Organic Molecules and Macromolecular Biomarkers Measured by Microarray Immunoassays and Their Astrobiological Implications."],"pmcid":["PMC6276817"],"pubmed_authors":["Parro V","Cavalcante-Silva E","Viudez-Moreiras D","Rodriguez-Manfredi JA","Davila AF","de Diego-Castilla G","Blanco Y","McKay CP"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Gamma and Electron Radiation on the Structural Integrity of Organic Molecules and Macromolecular Biomarkers Measured by Microarray Immunoassays and Their Astrobiological Implications.","description":"High-energy ionizing radiation in the form of solar energetic particles and galactic cosmic rays is pervasive on the surface of planetary bodies with thin atmospheres or in space facilities for humans, and it may seriously affect the chemistry and the structure of organic and biological material. We used fluorescent microarray immunoassays to assess how different doses of electron and gamma radiations affect the stability of target compounds such as biological polymers and small molecules (haptens) conjugated to large proteins. The radiation effect was monitored by measuring the loss in the immunoidentification of the target due to an impaired ability of the antibodies for binding their corresponding irradiated and damaged epitopes (the part of the target molecule to which antibodies bind)","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-25T18:18:09.649Z","creation":"2021-02-19T19:54:42Z"},"accession":"S-EPMC6276817","cross_references":{"pubmed":["30070898"],"doi":["10.1089/ast.2016.1645"]}}