{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saadane A"],"funding":["NEI NIH HHS","Research to Prevent Blindness","F. M. Kirby Foundation","National Institutes of Health"],"pagination":["2368-2382"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6277162"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["59(12)"],"pubmed_abstract":["Apolipoprotein E (APOE) is a component of lipid-transporting particles and a recognition ligand for receptors, which bind these particles. The APOE isoform ε2 is a risk factor for age-related macular degeneration; nevertheless, APOE absence in humans and mice does not significantly affect the retina. We found that retinal cholesterol biosynthesis and the levels of retinal cholesterol were increased in <i>Apoe<sup>-/-</sup></i> mice, whereas cholesterol elimination by metabolism was decreased. No focal cholesterol deposits were observed in the <i>Apoe<sup>-/-</sup></i> retina. Retinal proteomics identified the most abundant cholesterol-related proteins in WT mice and revealed that, of these cholesterol-related proteins, only APOA4 had increased expression in the <i>Apoe<sup>-/-</sup></i> re"],"journal":["Journal of lipid research"],"pubmed_title":["Mechanisms that minimize retinal impact of apolipoprotein E absence."],"pmcid":["PMC6277162"],"funding_grant_id":["P30 EY001583","EY015240","EY018383,","EY11373,","P30 EY011373","R01 EY018383","R01 EY015240"],"pubmed_authors":["El-Darzi N","Pikuleva IA","Mast N","Saadane A","Alnemri A","Petrov A","Dao T","Dunaief JL","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Mechanisms that minimize retinal impact of apolipoprotein E absence.","description":"Apolipoprotein E (APOE) is a component of lipid-transporting particles and a recognition ligand for receptors, which bind these particles. The APOE isoform ε2 is a risk factor for age-related macular degeneration; nevertheless, APOE absence in humans and mice does not significantly affect the retina. We found that retinal cholesterol biosynthesis and the levels of retinal cholesterol were increased in <i>Apoe<sup>-/-</sup></i> mice, whereas cholesterol elimination by metabolism was decreased. No focal cholesterol deposits were observed in the <i>Apoe<sup>-/-</sup></i> retina. Retinal proteomics identified the most abundant cholesterol-related proteins in WT mice and revealed that, of these cholesterol-related proteins, only APOA4 had increased expression in the <i>Apoe<sup>-/-</sup></i> re","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-07T12:28:51.179Z","creation":"2025-04-07T12:28:51.179Z"},"accession":"S-EPMC6277162","cross_references":{"pubmed":["30333155"],"doi":["10.1194/jlr.M090043","10.1194/jlr.m090043"]}}