biostudies-literatureUnknown18(4)Darnaud L<h4>Background</h4>Isavuconazole is a new antifungal prodrug for the treatment of invasive aspergillosis and mucormycosis. As no clear pharmacokinetic-pharmacodynamic relationship has been established for patients, therapeutic drug monitoring is not currently required. However, as isavuconazole is a new drug, clinicians are sometimes sceptical about the exposure achieved in their patients and seek pharmacokinetic exploration. A minimal response consists of determining that the patient's pharmacokinetic profile agrees with profiles reported by Desai et al. using concentrations from the SECURE study.<h4>Methods</h4>Based on one concentration and Desai et al.'s population-pharmacokinetic model, it is possible to estimate a patient's most likely pharmacokinetic profile. If a patient's pharmacoDrugs in R&D317-321https://www.ebi.ac.uk/biostudies/studies/S-EPMC6277320biostudies-literatureIsavuconazole Kinetic Exploration for Clinical Practice.PMC6277320Venisse NMartins PPontier SConcordet DDarnaud LGodet CLamoureux FDebard AGandia PfalseIsavuconazole Kinetic Exploration for Clinical Practice.<h4>Background</h4>Isavuconazole is a new antifungal prodrug for the treatment of invasive aspergillosis and mucormycosis. As no clear pharmacokinetic-pharmacodynamic relationship has been established for patients, therapeutic drug monitoring is not currently required. However, as isavuconazole is a new drug, clinicians are sometimes sceptical about the exposure achieved in their patients and seek pharmacokinetic exploration. A minimal response consists of determining that the patient's pharmacokinetic profile agrees with profiles reported by Desai et al. using concentrations from the SECURE study.<h4>Methods</h4>Based on one concentration and Desai et al.'s population-pharmacokinetic model, it is possible to estimate a patient's most likely pharmacokinetic profile. If a patient's pharmaco2018-01-01T00:00:00Z2018 Dec2025-05-29T21:45:14.796Z2025-05-29T21:45:14.796ZS-EPMC62773203030641510.1007/s40268-018-0251-y