{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan W"],"funding":["the Fundamental Research Funds for the Central Universities","National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["E2873"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6278401"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(11)"],"pubmed_abstract":["Five metabolites including two new ones, prochaetoviridin A (<b>1</b>) and chaetoindolin A (<b>2</b>), were isolated from the endophytic fungus <i>Chaetomium globosum</i> CDW7. Compounds <b>1</b> and <b>2</b> were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds <b>3</b>⁻<b>5</b> were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (<b>3</b>) exhibited antifungal activity against <i>Sclerotinia sclerotiorum</i> with an EC<sub>50</sub> value of 1.97 μg/mL. In vivo test showed that <b>3</b> displayed a "],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["New Metabolites from Endophytic Fungus <i>Chaetomium globosum</i> CDW7."],"pmcid":["PMC6278401"],"funding_grant_id":["KYZ201612","2017YFD0201100","21602109 and 31572043"],"pubmed_authors":["Cao LL","Zhang YY","Zhao R","Zhao SS","Ye YH","Yan W","Khan B"],"additional_accession":[]},"is_claimable":false,"name":"New Metabolites from Endophytic Fungus <i>Chaetomium globosum</i> CDW7.","description":"Five metabolites including two new ones, prochaetoviridin A (<b>1</b>) and chaetoindolin A (<b>2</b>), were isolated from the endophytic fungus <i>Chaetomium globosum</i> CDW7. Compounds <b>1</b> and <b>2</b> were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds <b>3</b>⁻<b>5</b> were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (<b>3</b>) exhibited antifungal activity against <i>Sclerotinia sclerotiorum</i> with an EC<sub>50</sub> value of 1.97 μg/mL. In vivo test showed that <b>3</b> displayed a ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-07-16T16:21:43.716Z","creation":"2019-03-27T00:11:42Z"},"accession":"S-EPMC6278401","cross_references":{"pubmed":["30400338"],"doi":["10.3390/molecules23112873"]}}