biostudies-literatureYan Wthe Fundamental Research Funds for the Central UniversitiesNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaE2873https://www.ebi.ac.uk/biostudies/studies/S-EPMC6278401biostudies-literatureUnknown23(11)Five metabolites including two new ones, prochaetoviridin A (<b>1</b>) and chaetoindolin A (<b>2</b>), were isolated from the endophytic fungus <i>Chaetomium globosum</i> CDW7. Compounds <b>1</b> and <b>2</b> were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds <b>3</b>⁻<b>5</b> were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (<b>3</b>) exhibited antifungal activity against <i>Sclerotinia sclerotiorum</i> with an EC₅₀ value of 1.97 μg/mL. In vivo test showed that <b>3</b> displayed a Molecules (Basel, Switzerland)New Metabolites from Endophytic Fungus <i>Chaetomium globosum</i> CDW7.PMC6278401KYZ2016122017YFD020110021602109 and 31572043Cao LLZhang YYZhao RZhao SSYe YHYan WKhan BfalseNew Metabolites from Endophytic Fungus <i>Chaetomium globosum</i> CDW7.Five metabolites including two new ones, prochaetoviridin A (<b>1</b>) and chaetoindolin A (<b>2</b>), were isolated from the endophytic fungus <i>Chaetomium globosum</i> CDW7. Compounds <b>1</b> and <b>2</b> were characterized as an isocoumarin and an indole alkaloid derivative, respectively, with their structures elucidated by comprehensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), NMR, and circular dichroism (CD) comparison. Compounds <b>3</b>⁻<b>5</b> were identified as chaetoviridin A, chaetoglobosin R, and chaetoglobosin T, respectively. Chaetoviridin A (<b>3</b>) exhibited antifungal activity against <i>Sclerotinia sclerotiorum</i> with an EC₅₀ value of 1.97 μg/mL. In vivo test showed that <b>3</b> displayed a 2018-01-01T00:00:00Z2018 Nov2026-07-16T16:21:43.716Z2019-03-27T00:11:42ZS-EPMC62784013040033810.3390/molecules23112873