{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shiota H"],"funding":["NCI NIH HHS","NIH","NIGMS NIH HHS"],"pagination":["1826-1833"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6279489"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(12)"],"pubmed_abstract":["Nuclear protein in testis (NUT) carcinoma (NC) is a rare, distinctly aggressive subtype of squamous carcinoma defined by the presence of <i>NUT</i>-fusion oncogenes resulting from chromosomal translocation. In most cases, the <i>NUT</i> gene (<i>NUTM1</i>) is fused to bromodomain containing 4 (<i>BRD4</i>) forming the <i>BRD4-NUT</i> oncogene. Here, a novel fusion partner to <i>NUT</i> was discovered using next-generation sequencing and FISH from a young patient with an undifferentiated malignant round cell tumor. Interestingly, the NUT fusion identified involved ZNF592, a zinc finger containing protein, which was previously identified as a component of the BRD4-NUT complex. In BRD4-NUT-expressing NC cells, wild-type ZNF592 and other associated \"Z4\" complex proteins, including ZNF532 and Z"],"journal":["Molecular cancer research : MCR"],"pubmed_title":["\"Z4\" Complex Member Fusions in NUT Carcinoma: Implications for a Novel Oncogenic Mechanism."],"pmcid":["PMC6279489"],"funding_grant_id":["R01 CA124633","R01 CA124633, R01CA124633-10S1, R01CA124633-10S2","R01 GM101958"],"pubmed_authors":["Barbash O","Elya JE","Gorman SA","Shiota H","Chou PM","Danga K","Nardi V","Kuroda MI","Alekseyenko AA","French CA","Becht K"],"additional_accession":[]},"is_claimable":false,"name":"\"Z4\" Complex Member Fusions in NUT Carcinoma: Implications for a Novel Oncogenic Mechanism.","description":"Nuclear protein in testis (NUT) carcinoma (NC) is a rare, distinctly aggressive subtype of squamous carcinoma defined by the presence of <i>NUT</i>-fusion oncogenes resulting from chromosomal translocation. In most cases, the <i>NUT</i> gene (<i>NUTM1</i>) is fused to bromodomain containing 4 (<i>BRD4</i>) forming the <i>BRD4-NUT</i> oncogene. Here, a novel fusion partner to <i>NUT</i> was discovered using next-generation sequencing and FISH from a young patient with an undifferentiated malignant round cell tumor. Interestingly, the NUT fusion identified involved ZNF592, a zinc finger containing protein, which was previously identified as a component of the BRD4-NUT complex. In BRD4-NUT-expressing NC cells, wild-type ZNF592 and other associated \"Z4\" complex proteins, including ZNF532 and Z","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2026-04-30T14:59:38.849Z","creation":"2024-10-18T12:30:53.571Z"},"accession":"S-EPMC6279489","cross_references":{"pubmed":["30139738"],"doi":["10.1158/1541-7786.MCR-18-0474","10.1158/1541-7786.mcr-18-0474"]}}