biostudies-literatureShiota HNCI NIH HHSNIHNIGMS NIH HHS1826-1833https://www.ebi.ac.uk/biostudies/studies/S-EPMC6279489biostudies-literatureUnknown16(12)Nuclear protein in testis (NUT) carcinoma (NC) is a rare, distinctly aggressive subtype of squamous carcinoma defined by the presence of <i>NUT</i>-fusion oncogenes resulting from chromosomal translocation. In most cases, the <i>NUT</i> gene (<i>NUTM1</i>) is fused to bromodomain containing 4 (<i>BRD4</i>) forming the <i>BRD4-NUT</i> oncogene. Here, a novel fusion partner to <i>NUT</i> was discovered using next-generation sequencing and FISH from a young patient with an undifferentiated malignant round cell tumor. Interestingly, the NUT fusion identified involved ZNF592, a zinc finger containing protein, which was previously identified as a component of the BRD4-NUT complex. In BRD4-NUT-expressing NC cells, wild-type ZNF592 and other associated "Z4" complex proteins, including ZNF532 and ZMolecular cancer research : MCR"Z4" Complex Member Fusions in NUT Carcinoma: Implications for a Novel Oncogenic Mechanism.PMC6279489R01 CA124633R01 CA124633, R01CA124633-10S1, R01CA124633-10S2R01 GM101958Barbash OElya JEGorman SAShiota HChou PMDanga KNardi VKuroda MIAlekseyenko AAFrench CABecht Kfalse"Z4" Complex Member Fusions in NUT Carcinoma: Implications for a Novel Oncogenic Mechanism.Nuclear protein in testis (NUT) carcinoma (NC) is a rare, distinctly aggressive subtype of squamous carcinoma defined by the presence of <i>NUT</i>-fusion oncogenes resulting from chromosomal translocation. In most cases, the <i>NUT</i> gene (<i>NUTM1</i>) is fused to bromodomain containing 4 (<i>BRD4</i>) forming the <i>BRD4-NUT</i> oncogene. Here, a novel fusion partner to <i>NUT</i> was discovered using next-generation sequencing and FISH from a young patient with an undifferentiated malignant round cell tumor. Interestingly, the NUT fusion identified involved ZNF592, a zinc finger containing protein, which was previously identified as a component of the BRD4-NUT complex. In BRD4-NUT-expressing NC cells, wild-type ZNF592 and other associated "Z4" complex proteins, including ZNF532 and Z2018-01-01T00:00:00Z2018 Dec2026-04-30T14:59:38.849Z2024-10-18T12:30:53.571ZS-EPMC62794893013973810.1158/1541-7786.MCR-18-047410.1158/1541-7786.mcr-18-0474