{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bersini S"],"funding":["NCI NIH HHS"],"pagination":["36110-36125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6281425"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(90)"],"pubmed_abstract":["The reciprocal interaction between circulating tumor cells (CTCs) and tissue-specific cells is influential for the progression of metastases. In particular, the process of extravasation relies on the complex cross-talk between cancer cells and other cellular players such as the endothelium and the secondary tissue. However, most <i>in vitro</i> studies only focus on one heterotypic cell-cell interaction and often lack of physiological relevance. In this project, we investigated both CTC-endothelium and CTC-secondary site interactions during cancer cell extravasation. We first used a microarray analysis of extravasated MDA-MB-231 breast cancer cells to identify key markers involved in extravasation. Then, we developed a tri-culture microfluidic platform combining cancer cells, endothelium a"],"journal":["Oncotarget"],"pubmed_title":["A combined microfluidic-transcriptomic approach to characterize the extravasation potential of cancer cells."],"pmcid":["PMC6281425"],"funding_grant_id":["U01 CA202177"],"pubmed_authors":["Moretti M","Miermont A","Kamm RD","Bersini S","Adriani G","Thiery JP","Pavesi A"],"additional_accession":[]},"is_claimable":false,"name":"A combined microfluidic-transcriptomic approach to characterize the extravasation potential of cancer cells.","description":"The reciprocal interaction between circulating tumor cells (CTCs) and tissue-specific cells is influential for the progression of metastases. In particular, the process of extravasation relies on the complex cross-talk between cancer cells and other cellular players such as the endothelium and the secondary tissue. However, most <i>in vitro</i> studies only focus on one heterotypic cell-cell interaction and often lack of physiological relevance. In this project, we investigated both CTC-endothelium and CTC-secondary site interactions during cancer cell extravasation. We first used a microarray analysis of extravasated MDA-MB-231 breast cancer cells to identify key markers involved in extravasation. Then, we developed a tri-culture microfluidic platform combining cancer cells, endothelium a","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-05-06T06:27:42.492Z","creation":"2019-10-30T08:14:29Z"},"accession":"S-EPMC6281425","cross_references":{"pubmed":["30546831"],"doi":["10.18632/oncotarget.26306"]}}