biostudies-literatureUnknown9(4)Ando HBoth peri-stent contrast staining (PSS) and late restenosis are abnormal findings after drug-eluting stent implantation and they occur with low incidence. We describe a case with two PSSs and one late restenosis after sirolimus-eluting stent implantation. Persistent high value of C-reactive protein in this patient suggested chronic systematic inflammation as a contributing factor of these abnormal findings. <Learning objective: The advent of drug-eluting stents has dramatically reduced in-stent restenosis. However, there are still some concerns about long-term safety. We show a case with multiple sirolimus-eluting stent-related complications, taking into account the underlying pathogenesis.>.Journal of cardiology cases145-147https://www.ebi.ac.uk/biostudies/studies/S-EPMC6281823biostudies-literatureTwo peri-stent contrast stainings and one late restenosis in the late phase after sirolimus-eluting stent implantation.PMC6281823Amano TTakashima HAndo HUetani TMurohara TfalseTwo peri-stent contrast stainings and one late restenosis in the late phase after sirolimus-eluting stent implantation.Both peri-stent contrast staining (PSS) and late restenosis are abnormal findings after drug-eluting stent implantation and they occur with low incidence. We describe a case with two PSSs and one late restenosis after sirolimus-eluting stent implantation. Persistent high value of C-reactive protein in this patient suggested chronic systematic inflammation as a contributing factor of these abnormal findings. <Learning objective: The advent of drug-eluting stents has dramatically reduced in-stent restenosis. However, there are still some concerns about long-term safety. We show a case with multiple sirolimus-eluting stent-related complications, taking into account the underlying pathogenesis.>.2014-01-01T00:00:00Z2014 Apr2025-04-21T15:02:10.326Z2019-03-27T00:13:09ZS-EPMC62818233054678610.1016/j.jccase.2013.12.008